Evaluating rapid rollover to prevent pneumothorax after lung biopsy
Effect of Post-Procedural Rapid Rollover on Pneumothorax After Percutaneous CT-Guided Lung Biopsy: A Randomized Controlled Trial
This study is testing if quickly rolling patients onto their side after a lung biopsy can help prevent lung collapse, known as pneumothorax.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 126 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of California, San Francisco Academic / other |
| Drugs / interventions | radiation |
| Locations | 2 sites (San Francisco, California and 1 other locations) |
| Trial ID | NCT05342675 on ClinicalTrials.gov |
What this trial studies
This study investigates the effectiveness of a technique called rapid rollover in reducing the incidence of pneumothorax following CT-guided lung biopsies. Patients will be randomly assigned to either a rapid rollover group, where they are repositioned with the biopsy site down immediately after the procedure, or a control group, where standard post-procedure care is provided. The study aims to determine if this maneuver can decrease the occurrence of pneumothorax and the need for chest tube insertion. Patients will be monitored for complications and undergo follow-up radiographs to assess for pneumothorax.
Who should consider this trial
Good fit: Ideal candidates include patients referred for CT-guided lung biopsy who do not have contraindications such as intra-procedural pneumothorax or specific lesion locations.
Not a fit: Patients with chest wall lesions, those who develop intra-procedural pneumothorax, or those unable to tolerate repositioning may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the risk of pneumothorax and the need for additional invasive procedures in patients undergoing lung biopsies.
How similar studies have performed: While the rapid rollover technique is a novel approach, similar studies have explored various methods to reduce pneumothorax risk, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients who are referred to the Department of Radiology and Biomedical Imaging Cardiac and Pulmonary Imaging section for CT-guided lung biopsy will be screened for eligibility. All eligible patients will be enrolled. Patients who develop intra-procedural pneumothorax will be analyzed but excluded from the final analysis. Exclusion Criteria: * Patients with chest wall, subpleural or mediastinal lesions * Patients who develop intra-procedural pneumothorax * Patients who are biopsied by a prone approach * Patients who are repositioned intra-procedurally * Patients who are unable to tolerate reposition or have spinal precautions * Patients who develop hemothorax and a chest tube is inserted for this indication
Where this trial is running
San Francisco, California and 1 other locations
- Zuckerberg San Francisco General Hospital and Trauma Center — San Francisco, California, United States (Recruiting)
- University of California, San Francisco — San Francisco, California, United States (Recruiting)
Study contacts
- Principal investigator: Jae Ho Sohn, MD — University of California, San Francisco
- Study coordinator: Jae Ho Sohn, MD
- Email: jaeho.sohn@ucsf.edu
- Phone: 415-476-1000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.