Evaluating platelet refractoriness in acute leukemia patients receiving filtered blood

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the incidence of platelet refractoriness in newly diagnosed acute leukemia patients receiving prestorage filtered blood (PFB) during their induction and first consolidation chemotherapy. It compares the outcomes of these patients with historical control groups who received non-leukocyte depleted blood products and leukocyte depleted blood products. The study will analyze data from Siriraj Hospital to determine the effectiveness and cost-effectiveness of using filtered blood products to prevent clinical platelet refractoriness. The researchers will calculate sample sizes based on previous incidence rates to ensure robust statistical analysis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Case group (PFB transfusion) Inclusion criteria

1. Newly diagnosed acute leukemia (either acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) patients underwent intensive chemotherapy
2. Age greater than 18 years
3. Participants receiving an induction chemotherapy and at least one cycle of consolidation chemotherapy

Exclusion Criteria:

1. Participants with positive platelet antibody detected by SPRCA method at presentation

Historical control group 1 (non-leukocyte depleted blood product) Inclusion criteria 1.Newly diagnosed acute leukemia (either AML or ALL) patients underwent intensive chemotherapy during 2018-2022 2. Age greater than 18 years 3. Participants receiving an induction chemotherapy and at least one cycle of consolidation chemotherapy 4. Participants receiving only non-leukocyte depleted blood products (LPB and LPPC) Exclusion criteria

1. Loss to follow up or death before completion of first consolidation chemotherapy
2. Participants receiving granulocyte infusion during time of study

Historical control group 2 (leukocyte depleted blood product) Inclusion criteria

1. Newly diagnosed acute leukemia (either AML or ALL) patients underwent intensive chemotherapy during 2018-2022
2. Age greater than 18 years
3. Participants receiving an induction chemotherapy and at least one cycle of consolidation chemotherapy
4. Participants receiving leukocyte depleted blood products (PFB and SDP) Exclusion criteria

1. Loss to follow up or death before completion of first consolidation chemotherapy during 2018-2022 2. Participants receiving granulocyte infusion during time of study 3. Participants receiving non-leukocyte depleted blood products greater than 20% of all transfused blood products during induction and first consolidation chemotherapy

Where it's running

• Siriraj hospital
  Bangkok, Thailand Recruiting

Study contacts

• Principal investigator: weerapat Owattanapanich, MD — Siriraj Hospital
• Study coordinator: weerapat Owattanapanich, MD
• Email: weerapato36733@gmail.com
• Phone: 0891081963

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.