Evaluating plaque characteristics to predict recurrent strokes in MCA stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the correlation between plaque characteristics observed through high-resolution MRI (HR-MRI) and the occurrence of recurrent strokes in patients who have experienced their first ischemic stroke due to middle cerebral artery (MCA) atherosclerosis. The study focuses on patients over 45 years old who have significant stenosis and have undergone a comprehensive stroke workup. By analyzing the complex pathology of atherosclerosis, the researchers hope to identify specific plaque features that could indicate a higher risk of recurrent strokes, thereby improving treatment strategies based on individual etiology.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients who had a first-time ischemic stroke due to MCA atherosclerosis stenosis more than 50% and admitted to our hospital within 7 days after onset.
* Patients are more than 45 years old.
* Patients had HR-MRI and have done the full stroke workup (including carotid duplex scanning, fasting lipid profile, Holter ECG 24 hours, cardiac ultrasound,...)

Exclusion Criteria:

* Patients also have stenosis of the carotid artery (more than 50%) or occulsion on the same side of ischemic stroke
* Patients also have an ischemic stroke in territories other than MCA territory.
* Patients had any characteristics that suggested other causes for their stenosis, including moyamoya, dissection, and inflammation on their MRI and HR-MRI.
* Patients with evidence suggestive of cardioembolism (Atrial fibrillation, decreased EF \<50%, recent heart attack in 3 weeks, rheumatic valvular heart disease, dilated cardiopathy, sick sinus syndrome, infective endocarditis).
* Any signs suggestive other causes (non atherosclerosis etiology), including autoimmune disease or increased coagulation state.
* Patients with severe concomitant disease could affect the 6-month follow-up of the patients.

Where it's running

• University Medical Center Ho Chi Minh City
  Ho Chi Minh City, Ho Chi Minh City, Vietnam Recruiting

Study contacts

• Principal investigator: Khoa Dao, MD — University Medical Center Ho Chi Minh City
• Study coordinator: Khoa Dao, MD
• Email: khoa.dd@umc.edu.vn
• Phone: +84986883254

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Imaging of atherosclerotic plaques in arteries using advanced MRI techniques

  This study is testing a new MRI technique to see if it can give better pictures of artery plaques in people with moderate to severe narrowing of the arteries, helping to understand their risk for stroke.

  Recruiting Shanghai Jiao Tong University Affiliated Sixth People's Hospital · Shanghai · NCT06754956

• Transcatheter closure versus medical therapy for PFO in older adults

  This tests whether closing a patent foramen ovale (PFO) with a catheter plus usual medicines prevents another unexplained (cryptogenic) stroke in people over 60 better than medicines alone.

  Recruiting Institut universitaire de cardiologie et de pneumologie de Québec, University Laval · Québec, Quebec and 1 other locations · NCT05907694

• Endovascular treatment outcomes after portal hypertension–related GI bleeding in cirrhosis

  This study tests how well endovascular procedures for portal hypertension–related GI bleeding work in adults with cirrhosis, and what factors predict outcomes.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City · NCT07918378

• How beta cells work in early-onset type 2 diabetes

  This project will test whether beta cell function and HbA1C change differently over one year in Vietnamese adults with early-onset versus typical-onset type 2 diabetes.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City, Cho Lon Ward · NCT07574138

• Bowel cleaning versus no bowel cleaning before laparoscopic right colectomy with internal (intracorporeal) anastomosis

  This trial will test whether doing a mechanical bowel preparation (bowel cleaning) before elective laparoscopic right hemicolectomy with intracorporeal anastomosis for stage I–III colon cancer changes surgical site infection rates and recovery.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City, Ho Chi Minh · NCT07546565

• Comparing more versus fewer needle agitations during EBUS-TBNA for mediastinal lymph node biopsy

  This test will see if using more or fewer needle agitations during EBUS-guided needle biopsies helps doctors obtain longer tissue cores and higher-quality samples in adults with enlarged mediastinal lymph nodes.

  Recruiting University Medical Center Ho Chi Minh City (UMC) · Ho Chi Minh City, Ho Chi Minh · NCT07424807

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.