Evaluating Photodynamic Therapy with Vitamin D for Periodontitis Management

Clinical Comparative Evaluation of the Use of Photodynamic Therapy in Conjunction With the Use of Vitamin D in Management Stage II Grade B Periodontitis Patients: A Randomized Controlled Clinical Trial.

This study is testing if adding Vitamin D to a light therapy treatment helps people with gum disease feel better compared to just using the light therapy alone.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 24 (estimated)
• Ages: 18 Years to 50 Years
• Sex: All
• Sponsor: Cairo University (Academic / other)
• Locations: 1 site (Cairo)
• Trial ID: NCT06700122 on ClinicalTrials.gov

What this trial studies

This clinical trial compares the effectiveness of Photodynamic Therapy (PDT) combined with Scaling and Root Planing (SRP) and Vitamin D against PDT with SRP alone in patients with Stage II Grade B Periodontitis. The study focuses on measuring clinical outcomes such as clinical attachment loss, probing pocket depth, and bleeding on probing. It aims to determine if the addition of Vitamin D enhances the therapeutic effects of PDT in managing periodontal disease. Participants will be randomly assigned to one of the two treatment groups for evaluation.

Who should consider this trial

Good fit: Ideal candidates are systemic healthy individuals over 25 years old with Stage II Grade B Periodontitis and specific clinical attachment loss.

Not a fit: Patients with a history of previous periodontal therapy or those on medications that interfere with healing may not benefit from this study.

Why it matters

Potential benefit: If successful, this approach could improve periodontal health outcomes for patients suffering from Stage II Grade B Periodontitis.

How similar studies have performed: While there is limited data on the specific combination of PDT and Vitamin D, similar studies have shown promising results with PDT in periodontal treatment.

Eligibility criteria

Inclusion Criteria:

* Systemic healthy patients
* Patients aged \> 25 years
* Patients suffering from stage II periodontitis with grade B were included in this study, according to 2017 world workshop classification of periodontal disease.
* Patients with interdental clinical attachment loss (CAL) of 3-4 mm with radiographic evidence of bone loss extending to coronal third of the root.
* Radiographic bone loss (RBL) will be diagnosed using periapical parallel technique using 6 radiographic images for full mouth (3- radiographic images for maxillary arch and 3- radiographic images for mandibular arch) including anterior, canine region and posterior teeth at baseline for diagnosis.
* No history of previous periodontal therapy.
* No taken medications known to interfere healing or periodontal tissue health such as anticonvulsants, calcium channel blockers, or immunosuppressant drugs.
* No previous periodontal surgery at involved sites.
* Good oral hygiene and good compliance with the plaque control instructions following initial therapy.
* Neither taken antibiotics within the last three months nor nonsteroidal anti-inflammatory drugs within the last three months
* Absence of diseases or conditions that would interfere with wound healing such as diabetes mellitus or coagulation disorders

Exclusion Criteria:

Patients taking Vitamin D as a nutritional supplement were excluded from the study

* Smoking habits
* Pregnant and lactating mothers
* Patients who have been received periodontal surgery in the study area during the last 6 months.

Where this trial is running

Cairo

• Marwa Helal — Cairo, Egypt (Recruiting)

Study contacts

• Principal investigator: Marwa Helal — Cairo University
• Study coordinator: Marwa Helal

Conditions Vitamin D Deficiency