Evaluating PCI for Chronic Total Coronary Occlusion

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of percutaneous coronary intervention (PCI) in patients with chronic total occlusion (CTO) of coronary arteries, in conjunction with optimal medical therapy. It involves a randomized registry approach to assess outcomes in patients who have stable coronary artery disease and specific symptoms or indications of reversible ischemia. Participants will be monitored for improvements in their condition following the intervention.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥1 CTO lesion amenable to PCI.
* Stable and stabilized coronary artery disease
* Symptoms (angina pectoris or shortness of breath) and/or signs of reversible perfusion defect by SPECT, PET or MR and/or angiographic/echocardiographic indication of reversible ischemia.
* CTO lesion in a major coronary vessel supplying a significant myocardial territory (vessel diameter usually ≥3mm).

Exclusion Criteria:

* Expected survival \<1 year.
* Renal failure on dialysis.
* Stable non-CTO lesions treated within one month.
* Declined informed consent.
* Regarding CMR: allergy to contrast medium, severe obesity, claustrophobia and certain metallic implants

Where it's running

• Aalborg University Hospital
  Aalborg, Denmark Recruiting

Study contacts

• Study coordinator: Martin K Christensen, MD
• Email: m.kirk@rn.dk
• Phone: +45 9766 4454

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.