Evaluating pain relief methods after dental procedures
Effect of Different Intraligamentary Injections on the Post-endodontic Pain in Patients With Symptomatic Irreversible Pulpitis
This study is testing which pain relief injection works best for people with tooth pain after dental treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 140 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | All |
| Sponsor | Jamia Millia Islamia Academic / other |
| Locations | 1 site (New Delhi) |
| Trial ID | NCT06186921 on ClinicalTrials.gov |
What this trial studies
This study evaluates postoperative pain in patients with symptomatic irreversible pulpitis following intraligamentary injections of dexamethasone, diclofenac sodium, bupivacaine, or lidocaine after dental treatment. Patients will first receive a standard inferior alveolar nerve block, and those without adequate numbness will be excluded. After endodontic treatment, pain levels will be assessed at multiple time points using a visual analog scale to compare the effectiveness of the different injection types. The study aims to identify which injection provides the best pain relief.
Who should consider this trial
Good fit: Ideal candidates are patients with symptomatic carious exposed mandibular molars who are able to understand pain scales.
Not a fit: Patients with multiple active dental issues, known allergies to anesthetics, or those on medications affecting pain perception may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing dental procedures.
How similar studies have performed: Previous studies have shown varying success with similar pain management approaches, but this specific combination of treatments is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Symptomatic carious exposed mandibular first or second molars. * Positive and prolonged response to thermal sensitivity tests and electric pulp tests. * Vital coronal pulp on access cavity preparation. * American Society of Anesthesiologists class I or II medical history. * Ability to understand the use of pain scales. Exclusion Criteria: * Active pain in more than 1 tooth * Teeth with fused roots. * Radiographic evidence of an extra root. * Large restorations with overhanging margins. * Full crowns or deep periodontal pockets. * Known allergy or contraindications to any content of the local anesthetic solution or NSAIDs * History of known or suspected drug abuse. * Taking any drugs which could affect the pain perception, e.g, opioids, antidepressants, anticonvulsants, muscle relaxants, anxiolytics, sedatives, NSAIDs. * Pregnant or breastfeeding patients. * Patients with asthma, gastric ulcers, and bleeding disorders.
Where this trial is running
New Delhi
- Faculty of Dentistry, Jamia MIliia Islamia — New Delhi, India (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.