Evaluating pain and activity levels after orthodontic separators

Pain Intensity Following the Placement of Orthodontic Separators in Healthy Volunteers and How it Correlates to Different Levels of Physical Activity?

Not applicable Interventional University of Kentucky · NCT05615688

This study is testing whether being more physically active helps people aged 18-49 feel less pain after getting orthodontic separators placed in their mouths.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment94 (estimated)
Ages18 Years to 49 Years
SexAll
SponsorUniversity of Kentucky Academic / other
Locations1 site (Lexington, Kentucky)
Trial IDNCT05615688 on ClinicalTrials.gov

What this trial studies

This study aims to assess the pain intensity experienced by healthy volunteers aged 18-49 following the placement of orthodontic separators. It hypothesizes that individuals with higher physical activity levels will report less pain compared to their less active counterparts. Participants will record their daily step counts and pain levels at 24-hour intervals over a week after separator placement. The study seeks to understand the relationship between physical activity and pain perception in orthodontic treatment.

Who should consider this trial

Good fit: Ideal candidates are healthy individuals aged 18-49 who are students, residents, or staff at the University of Kentucky with specific dental criteria.

Not a fit: Patients with chronic pain conditions or those currently using pain medications may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could help improve pain management strategies for patients undergoing orthodontic treatment.

How similar studies have performed: While there have been studies on pain perception in orthodontics, this specific approach linking physical activity levels to pain intensity is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Student, resident, or staff at the University of Kentucky
* Aged 18-49 at time of enrollment in the study
* Erupted permanent first and second molars with interproximal contacts
* Presence of antagonist teeth in the opposite arch with no open bite
* Voluntary participation in study
* Access to a smartphone, tablet, or computer
* Valid email address

Exclusion Criteria:

* Any chronic pain condition (examples include trigeminal neuralgia, migraines, fibromyalgia, arthritis, neuropathies)
* Current use of pain medication (analgesics, opioids, nerve pain medications) for any condition
* Clinically evident interproximal decay in the site where separators will be placed
* Missing teeth, variations in tooth anatomy, existing space, and or restorations that would keep separators from being placed or retained
* If you do not have access to a computer, smartphone, or tablet with internet access

Where this trial is running

Lexington, Kentucky

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Dental Malocclusion
Last reviewed 2026-06-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.