Evaluating Oxygen Reserve Index and End-Tidal Carbon Dioxide during Apnea Tests for Brain Death Diagnosis
Evaluation of the Relationship of Oxygen Reserve Index (ORI) and End-Tidal Carbon Dioxide (ETCO₂) With Arterial Blood Gas Parameters During the Apnea Test
This study is testing if a new non-invasive tool for measuring oxygen levels can help doctors better understand brain death during apnea tests, making the process easier for patients.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 35 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Bursa Yüksek İhtisas Education and Research Hospital Government |
| Locations | 1 site (Bursa) |
| Trial ID | NCT06983990 on ClinicalTrials.gov |
What this trial studies
This observational study evaluates the relationship between the Oxygen Reserve Index (ORI) and End-Tidal Carbon Dioxide (ETCO2) values with arterial blood gas parameters in patients undergoing an apnea test for brain death diagnosis. It aims to assess the effectiveness of ORI in evaluating oxygenation and its applicability compared to traditional methods. The study will monitor the correlation between ORI and partial arterial oxygen pressure (PaO2), as well as between ETCO2 and partial arterial carbon dioxide pressure (PaCO2). By using a non-invasive monitoring tool, the study seeks to reduce the need for invasive arterial blood sampling during the apnea test.
Who should consider this trial
Good fit: Ideal candidates include patients aged 18 years or older who are undergoing the apnea test for brain death diagnosis and have consent from their first-degree relatives.
Not a fit: Patients whose first-degree relatives do not consent or who have circulatory disturbances preventing the use of the ORI probe may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a non-invasive method for more accurately assessing oxygenation during brain death diagnosis.
How similar studies have performed: While the use of ORI is relatively novel, similar studies have shown promise in non-invasive monitoring techniques, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who meet all the prerequisites for initiating the brain death diagnosis process and for whom the decision to perform the apnea test for diagnosis of brain death. * Patients aged 18 years or older. * Patients who have provided verbal and written consent from their first-degree relatives. Exclusion Criteria: * Patients whose first-degree relatives do not consent to participation in the study. * Patients in whom the ORI probe cannot be used due to circulatory disturbances in the extremities
Where this trial is running
Bursa
- Health Sciences University Bursa Yüksek İhtisas Training and Research Hospital — Bursa, Turkey (Recruiting)
Study contacts
- Principal investigator: Nilay SERTDEMIR, MD — Health Sciences University Bursa Yüksek İhtisas Training and Research Hospital
- Study coordinator: Nilay SERTDEMIR, MD
- Email: nilaygulsenn@gmail.com
- Phone: +905357408240
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.