Evaluating oxygen and sevoflurane delivery in anesthesia based on lung function
Oxygen Consumption and Sevoflurane Uptake Based on Physiological Dead Space Estimation During Closed Circuit Anesthesia: A Prospective Interventional Study
NA · Fundación Pública Andaluza para la gestión de la Investigación en Sevilla · NCT05511584
This study tests if a new way of delivering oxygen and anesthesia can improve safety and results for patients having robotic prostate surgery.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 17 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | All |
| Sponsor | Fundación Pública Andaluza para la gestión de la Investigación en Sevilla (other) |
| Locations | 1 site (Seville) |
| Trial ID | NCT05511584 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the accuracy of oxygen consumption and sevoflurane uptake estimations in patients undergoing robotic prostatic surgery. By calculating these estimations based on the physiological dead space, the researchers will determine how well the delivered gases match actual consumption during anesthesia. Participants will be ventilated using a tailored open lung approach, allowing for precise adjustments in gas delivery. The study focuses on improving anesthetic management in a closed circuit mode to enhance patient safety and outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adult patients scheduled for robotic prostatic surgery who can provide informed consent.
Not a fit: Patients with severe respiratory or cardiac conditions, or those with significant obesity, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more accurate dosing of anesthetic gases, improving patient safety and outcomes during surgery.
How similar studies have performed: While the approach of estimating gas delivery based on physiological dead space is innovative, similar studies have shown promise in improving anesthetic management.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult subjects (≥ 18 years) scheduled for robotic prostatic surgery at the investigators´ institution * Written informed consent Exclusion Criteria: * Participation in another interventional study * Participants unable to understand the information contained in the informed consent * American Society of Anesthesiologists (ASA) classification grade = IV * Patient in dialysis * Chronic obstructive pulmonary disease (COPD) grade Global Initiative for Chronic Obstructive Lung Disease(GOLD) \> 2 * Functional vital capacity \< 60% or \> 120% of the predicted * Body mass index (BMI) \> 35 kg/m2 * Relation arterial pressure of oxygen (PaO2)/FiO2 \<200 mmHg in the baseline sample * Presence of mechanical ventilation in the 72 hours prior to enrollment * New York Heart Association (NYHA) functional class ≥ 3 * Clinically suspected heart failure * Diagnosis or suspicion of intracranial hypertension * Presence of pneumothorax or giant bullae on preoperative imaging tests * Use of Continuous Positive Airway Pressure (CPAP).
Where this trial is running
Seville
- Hospital Universitario Virgen del Rocío — Seville, Spain (RECRUITING)
Study contacts
- Principal investigator: Manuel de la Matta, MD — Hospitales Universitarios Virgen del Rocío
- Study coordinator: Manuel de la Matta, MD
- Email: mdlmatta@hotmail.com
- Phone: 0034 647 49 33 62
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Oxygen Consumption, Sevoflurane, Anesthetics, Inhalation, Surgery, Anesthesia, Closed-Circuit