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Evaluating outcomes of endovascular abdominal aortic aneurysm repair

JAGUAR Trial: ObJective Analysis to GaUge EVAR Outcomes Through Randomization

Not applicable Interventional Endologix · NCT05064540

This study is testing two different devices for repairing abdominal aortic aneurysms to see which one works better for patients over time.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment450 (estimated)
Ages21 Years and up
SexAll
SponsorEndologix Industry-sponsored
Locations29 sites (Huntsville, Alabama and 28 other locations)
Trial IDNCT05064540 on ClinicalTrials.gov

What this trial studies

This prospective, randomized, multi-center study aims to assess the outcomes of contemporary endovascular abdominal aortic aneurysm (EVAR) devices in a real-world population. Patients will be randomly assigned to two different device cohorts and their outcomes will be compared across primary endpoints. Follow-up evaluations will occur at discharge, and at 1, 6, 12 months, and annually for up to 5 years to monitor long-term results.

Who should consider this trial

Good fit: Ideal candidates include adults aged 21 and older with unruptured infrarenal abdominal aortic aneurysms who are eligible for endovascular repair.

Not a fit: Patients currently participating in another trial or those with known allergies to device components may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment options and outcomes for patients with abdominal aortic aneurysms.

How similar studies have performed: Other studies have shown success with similar randomized approaches in evaluating EVAR outcomes, indicating a promising avenue for this trial.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Adult age 21 and older
* Subjects with minimum of 2 year life expectancy
* Subjects have signed the informed consent document
* Subjects with unruptured infrarenal AAA who are assessed by the Investigator to be eligible for endovascular Abdominal Aortic Aneurysm Repair with the trial devices.
* Patient must be able and willing to comply with all required follow-up exams.

Exclusion Criteria:

* Currently participating in another trial where the primary endpoint has not been reached yet.
* Known allergy to any of the device components
* Pregnant (females of childbearing potential only)
* Known connective tissue disorders
* Known active infection
* Subjects with pre-existing EVAR, i.e., in need of repair/intervention of a previously failed EVAR.
* Patient has other medical, social, or psychological conditions that, in the opinion of the investigator, preclude them from receiving the pre-treatment, required treatment, and post-treatment procedures and evaluations.

Where this trial is running

Huntsville, Alabama and 28 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
View on ClinicalTrials.gov → Find more trials like this →
Conditions AAAAAA - Abdominal Aortic Aneurysmrandomized
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.