Evaluating outcomes and side effects of salvage treatment for recurrent breast cancer
Official title: A Prospective Registry Study to Evaluate Oncologic Outcomes and Toxicities of Salvage Treatment in Patients With Locoregionally Recurrent Breast Cancer
Run by Samsung Medical Center · NCT05933733 · Data updated 2026-11-12
This study is testing how well salvage treatments work and what side effects they cause in women with recurring breast cancer that hasn't spread to other parts of the body.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | Women only |
| Enrollment | 190 (estimated) |
| Sponsor | Samsung Medical Center Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Seoul) |
| Status | Recruiting |
| Started | July 4, 2023 |
| Main results expected | July 2028 |
| Study ends | July 2033 |
| Registry record updated | June 29, 2025 |
| Trial ID | NCT05933733 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are female patients aged 18 to 100 who have experienced locoregional recurrence of breast cancer after initial definitive treatment.
✕Probably not a fit
Patients who do not meet the eligibility criteria or are not anticipated to comply with the study protocol may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the clinical outcomes and adverse events associated with salvage treatment in patients experiencing locoregional recurrence of breast cancer. It will evaluate disease status, quality of life, and molecular signatures related to treatment resistance through various assessments, including physical examinations, radiologic evaluations, and patient questionnaires. The study will focus on female patients who have previously undergone definitive treatment for breast cancer and are now facing recurrence without distant metastasis.
Why it matters
Potential benefit: If successful, this study could provide valuable insights into effective salvage treatment strategies and improve quality of life for patients with recurrent breast cancer.
How similar studies have gone: While there have been studies on salvage treatments for breast cancer, this specific observational approach focusing on outcomes and molecular signatures is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients with age 18 to 100. * Previous standard definitive treatment for initial breast cancer * Locoregional recurrence without distant metastasis * Planned salvage treatment for locoregional recurrence * Informed consent of the participant Exclusion Criteria: \- Not anticipated for complying the study protocol
Where it's running
-
Samsung Medical Center
Seoul, South Korea Recruiting
Study contacts
- Principal investigator: Haeyoung Kim — Samsung Medical Center
- Study coordinator: Haeyoung Kim, MD, PhD
- Email: haeyoung0131.kim@samsung.com
- Phone: 82-2-3410-2612
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Gyrotonic exercise for elders with breast cancer and Behcet disease
We’re testing whether a gyrotonic exercise program helps older people who have both Behcet disease and breast cancer.
-
PECS II vs SPSIP nerve blocks for pain after mastectomy
This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.
-
CG-7321: a first-in-human test in advanced solid tumors
We’re testing CG-7321 alone and with fulvestrant to see if it’s safe and tolerable in adults with advanced solid tumors.
-
Compare a new endoscopy-assisted breast-conserving surgery with the usual approach
This study tests whether a new endoscopy-assisted breast-conserving technique can provide similar or better cosmetic outcomes and safety compared with conventional breast-conserving surgery in women with early breast cancer who want to preserve their breast.
-
Different skin care approaches to prevent skin reactions after mastectomy radiation
This study tests three standard skin care methods to see which best prevents radiation dermatitis in people who had a mastectomy and are receiving post-mastectomy radiation therapy.
-
3D Heart Strain to Detect Early Cardiotoxicity in Cancer Therapy
This study tests whether 3D echocardiography can detect early heart damage from cancer treatments like anthracyclines or HER2-targeted therapy better than standard 2D methods.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.