Evaluating non-invasive methods for predicting kidney failure in patients with liver complications
Official title: Non-invasive Evaluation of the Predictive Value of CEUS and SWE in Patients With and Without TIPS With ACLF, Renal Failure and Hepatorenal Syndrome
Run by University Hospital, Bonn · NCT04446858 · Data updated 2026-11-12
This study is testing if new non-invasive methods can help predict kidney failure in patients with liver problems, both with and without a specific treatment called TIPS.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | University Hospital, Bonn Academic / other |
| Locations | 1 site (Bonn) |
| Status | Recruiting |
| Started | January 1, 2021 |
| Main results expected | July 1, 2030 |
| Study ends | July 1, 2030 |
| Registry record updated | May 18, 2022 |
| Trial ID | NCT04446858 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include patients with portal hypertension and kidney failure.
✕Probably not a fit
Patients without kidney failure or portal hypertension will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the prognostic value of non-invasive assessments in patients experiencing acute-on-chronic liver failure (ACLF) and renal failure, both with and without the intervention of transjugular intrahepatic portosystemic shunt (TIPS). It involves a structured follow-up program where clinical and laboratory data are collected and analyzed to identify potential predictive markers. The study aims to enhance understanding of kidney failure progression in the context of liver disease using advanced imaging techniques and biomarkers.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic tools for managing kidney failure in patients with liver complications.
How similar studies have gone: Other studies have explored similar non-invasive approaches, but the specific combination of techniques in this study is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients with portal hypertension and kidney failure Exclusion Criteria: * no consent, no kidney failure, no portal hypertension
Where it's running
-
University Hospital Bonn
Bonn, Germany Recruiting
Study contacts
- Principal investigator: Michael Praktiknjo, MD — University Hospital, Bonn
- Study coordinator: Michael Praktiknjo, MD
- Email: michael.praktiknjo@ukbonn.de
- Phone: +49(0)228-287 15770
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Using muscle relaxants to improve electroporation ablation safety
This study tests if using muscle relaxants during a heart procedure called electroporation ablation can make it safer for patients and help them recover faster.
-
Project to improve understanding and treatment of kidney diseases
This study is trying to find better ways to understand and treat kidney diseases by looking closely at kidney samples and patient data to help create personalized care plans.
-
How knee and hip joint replacements are doing over time
This observational study follows adults who have knee or hip replacements to see how their outcomes look over time after the surgery.
-
Enhanced vision and imaging tests to enable treatments for early and intermediate AMD
We will see if a fundus-tracked dark adaptometry test can reliably detect and track vision changes in people with early or intermediate AMD and in healthy volunteers.
-
Increasing daily physical activity to slow cognitive decline in alpha-synuclein disorders
This study will test whether using a motivational smartphone app to increase everyday physical activity can help slow cognitive decline in people aged 50–80 with isolated REM sleep behavior disorder (an early sign of alpha‑synuclein disease).
-
Microdialysis monitoring of antibiotic release after hip spacer surgery
This project will use microdialysis to test whether antibiotics released from a cement spacer reach therapeutic levels in the hip joint and relate to infection-free recovery in adults having two-stage revision for periprosthetic hip infection.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.