Clinical trial Recruiting at 1 site Observational Ages 18 to 100

Evaluating non-invasive methods for predicting kidney failure in patients with liver complications

Official title: Non-invasive Evaluation of the Predictive Value of CEUS and SWE in Patients With and Without TIPS With ACLF, Renal Failure and Hepatorenal Syndrome

Run by University Hospital, Bonn · NCT04446858 · Data updated 2026-11-12

This study is testing if new non-invasive methods can help predict kidney failure in patients with liver problems, both with and without a specific treatment called TIPS.

Quick facts

Study typeObservational
Ages18 Years to 100 Years
SexAll
Enrollment1000 (estimated)
SponsorUniversity Hospital, Bonn
Academic / other
Locations1 site (Bonn)
StatusRecruiting
StartedJanuary 1, 2021
Main results expectedJuly 1, 2030
Study endsJuly 1, 2030
Registry record updatedMay 18, 2022
Trial IDNCT04446858 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include patients with portal hypertension and kidney failure.

Probably not a fit

Patients without kidney failure or portal hypertension will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the prognostic value of non-invasive assessments in patients experiencing acute-on-chronic liver failure (ACLF) and renal failure, both with and without the intervention of transjugular intrahepatic portosystemic shunt (TIPS). It involves a structured follow-up program where clinical and laboratory data are collected and analyzed to identify potential predictive markers. The study aims to enhance understanding of kidney failure progression in the context of liver disease using advanced imaging techniques and biomarkers.

Why it matters

Potential benefit: If successful, this study could lead to improved prognostic tools for managing kidney failure in patients with liver complications.

How similar studies have gone: Other studies have explored similar non-invasive approaches, but the specific combination of techniques in this study is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* All patients with portal hypertension and kidney failure

Exclusion Criteria:

* no consent, no kidney failure, no portal hypertension

Where it's running

  • University Hospital Bonn
    Bonn, Germany
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.