Evaluating non-invasive methods for diagnosing portal hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the effectiveness of measuring liver and spleen stiffness as non-invasive diagnostic tools for Porto-Sinusoidal Vascular Diseases (PSVD) in patients who have undergone platinum-based chemotherapy. The study will involve a single-center, prospective approach to gather data on the correlation between stiffness measurements and the diagnosis of PSVD, traditionally reliant on invasive liver biopsies. Additionally, the research seeks to identify potential biomarkers that could enhance the diagnostic process for PSVD.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Received platinum chemotherapy for organ tumors;
2. Ages 18-80;
3. sign the informed consent voluntarily.

Exclusion Criteria:

1. Liver pathology suggested cirrhosis;
2. Underwent liver transplantation;
3. Combined with hepatocellular carcinoma exceeding Milan criteria;
4. Complicated with severe heart, kidney, or lung failure;
5. Pregnant or lactating women;
6. Data is seriously missing;
7. Patients were judged not suitable for participation in this study by the researchers.

Where it's running

• Nanfang hospital, Southern Medical Uiversity
  Guangzhou, Guangdong, China Recruiting

Study contacts

• Principal investigator: Xiaofeng Zhang — Nanfang Hospital, Southern Medical University
• Study coordinator: Xiaofeng Zhang
• Email: 1282614092@qq.com
• Phone: +8618565552050

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Comparing HVPG and endoscopic ultrasound portal pressure measurements

  This study will test whether an endoscopic ultrasound method (EUS-PPG) gives the same portal pressure readings as the standard hepatic venous pressure gradient (HVPG) in adults who need portal pressure measurement.

  Recruiting at 2 sites Military University Hospital, Prague · Prague, Bohemia and 1 other locations · NCT07424963

• Registry for patients undergoing TIPS implantation for portal hypertension

  This study is collecting information from patients with serious portal hypertension who are getting a TIPS procedure to see how well it works and what complications might happen afterward.

  Recruiting University Hospital Freiburg · Freiburg im Breisgau · NCT05782556

• Predicting liver failure after surgery in patients with chronic liver disease

  This study is trying to find out what causes liver failure after surgery in people with chronic liver disease to help doctors better predict risks for their patients.

  Recruiting University Hospital, Bonn · Bonn · NCT04578301

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.