Evaluating non-drug methods to prevent dementia in elderly with mild cognitive impairment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to assess the effectiveness of a non-pharmacological intervention program designed to prevent the progression from mild cognitive impairment to dementia in elderly patients. The program includes home-based and supervised cognitive training exercises tailored to the Vietnamese population, addressing the unique cultural and linguistic needs of participants. By focusing on early-stage cognitive decline, the study seeks to leverage the remaining cognitive abilities of participants to maximize benefits. The interventions are designed to be user-friendly and accessible for the elderly, avoiding reliance on technology that may not be suitable for this demographic.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects diagnosed with mild cognitive impairment:

  * Cognitive complaints from the subject or a family member.
  * Report a decline in cognitive function compared to the subject's previous ability over the past year OR
  * Evidence from clinical assessment, specifically here is MMSE screening with results of 24-29 points.
  * Subjects did not suffer major impacts from cognitive complaints on daily life.
  * No prior diagnosis of dementia.
* Ensure transportation from living location to hospital.
* Have at least one relative or caregiver who can supervise the subject's daily activities.
* Stable chronic underlying conditions (diabetes, hypertension).
* Consent to participate in the study.

Exclusion Criteria:

* Don't know Vietnamese writing.
* Audio-visual ability does not meet the requirements of assessment tests and prevention programs.
* Systemic diseases are contraindications/ restriction to participation in programs and/or cause secondary cognitive impairment (traumatic brain injury, stroke, brain tumor, parkinsonism, epilepsy, acute coronary artery disease, acute myocardial infarction, bone fractures...).
* The assessment score on the Geriatric Depression Scale (GDS-15) is ≥ 5 points.
* Diagnosed with other mental disorders that may limit the ability to understand, communicate and work in groups (schizophrenia, mania, bipolar disorder, dissociative disorder, generalized anxiety disorder).
* Currently participating in another research program on dementia prevention or a research program on medication to prevent dementia within the last 3 months.
* Taking medications that may affect cognitive function, such as benzodiazepines, hypnotics, and antipsychotics.
* Alcohol abuse: drinking alcohol daily or consuming more than 14 units of alcohol per week (equivalent to 10 grams of ethanol, as defined by the Ministry of Health); diagnosed with alcohol dependence or currently being treated for mental illness due to alcohol dependence.
* Do not agree to participate in the study.

Where it's running

• Nhân dân Gia Định Hospital
  Ho Chi Minh City, Vietnam Recruiting

Study contacts

• Study coordinator: Khai Q. Nguyen, M.D
• Email: nguyenquangkhai2209@gmail.com
• Phone: +84704674558

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.