Evaluating new CT imaging methods that use less radiation

Prospective Evaluation of Next Generation CT Reconstruction

This study is testing new CT imaging methods that use less radiation to see if they can still produce clear images for adults needing scans of their chest, abdomen, or pelvis.

Quick facts

• Study type: Observational
• Enrollment: 215 (estimated)
• Ages: 18 Years to 99 Years
• Sex: All
• Sponsor: National Institutes of Health Clinical Center (CC) (nih)
• Drugs / interventions: radiation
• Locations: 1 site (Bethesda, Maryland)
• Trial ID: NCT02417714 on ClinicalTrials.gov

What this trial studies

This observational study aims to assess whether new computed tomography (CT) imaging techniques that utilize reduced radiation levels produce images comparable to those generated by traditional CT methods. Participants, who are adults scheduled for a CT scan of the chest, abdomen, or pelvis with contrast, will have their medical records reviewed and may undergo blood tests to ensure safety for contrast use. The study focuses on understanding the effectiveness and safety of these innovative imaging approaches in a clinical setting.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who require a CT scan of the chest, abdomen, or pelvis with contrast.

Not a fit: Patients who are pregnant or have certain medical conditions, such as elevated serum creatinine levels, may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to safer CT imaging methods that minimize radiation exposure for patients.

How similar studies have performed: Other studies have explored similar radiation-reduction techniques in CT imaging, showing promising results in image quality and safety.

Eligibility criteria

* INCLUSION CRITERIA:

Inclusion Criteria for Body CT:

1. Clinical indication for a chest, abdomen and pelvis CT with contrast
2. Age equal to or greater than 18 years
3. Able to understand and willing to sign the Informed Consent Form

Inclusion Criteria for Chest CT:

1. Clinical indication for a CT with or without contrast that includes the chest
2. Age equal to or greater than 18 years
3. Able to understand and willing to sign the Informed Consent Form

EXCLUSION CRITERIA:

Exclusion Criteria for Body CT:

1. Pregnancy
2. Serum Cr \> 1.5 mg/dL
3. Clinical CT scan with more than one contrast imaging phase (for example three phase liver)

Exclusion Criteria for Chest CT

1\. Pregnancy

Where this trial is running

Bethesda, Maryland

• National Institutes of Health Clinical Center — Bethesda, Maryland, United States (RECRUITING)

Study contacts

• Principal investigator: Marcus Y Chen, M.D. — National Heart, Lung, and Blood Institute (NHLBI)
• Study coordinator: Margaret C Lowery, R.N.

Conditions: Healthy Subjects, Computed Tomography, Radiation Reduction, Iterative Reconstruction, Natural History