Evaluating new biomarkers for lung health checks
Assessment of Novel Biomarkers in Participants Undergoing Targeted Lung Health Checks
This study is testing new biological markers in people getting lung health checks to see if they can help find serious lung cancers earlier and reduce unnecessary treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10000 (estimated) |
| Ages | 55 Years to 74 Years |
| Sex | All |
| Sponsor | University College, London Academic / other |
| Locations | 1 site (London) |
| Trial ID | NCT05902559 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess novel biomarkers in participants undergoing targeted lung health checks, particularly focusing on low-dose CT screening for lung cancer. The study seeks to improve the identification of clinically significant lung cancers by integrating biomarker analysis from minimally invasive samples with traditional imaging techniques. By addressing the challenges of distinguishing between benign and malignant nodules, the research hopes to enhance early detection and reduce unnecessary treatments. Participants will be recruited from the NHS Targeted Lung Health Check program.
Who should consider this trial
Good fit: Ideal candidates are adults aged 55 to 74 who have participated in the NHS Targeted Lung Health Check program.
Not a fit: Patients who decline participation or are deemed unfit for enrollment will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection of lung cancer, reducing mortality and unnecessary treatments for patients.
How similar studies have performed: Other studies have shown promise in using biomarkers alongside imaging for lung cancer detection, indicating a potential for success in this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Attended one of more visits as part of the NCL NHS TLHC programme * Adults aged between 55 years and 74 years and 364 days * Have capacity and can provide written consent Exclusion Criteria: * Declines participation in ALPINE * Lacking capacity and unable to provide written consent * Patients who are considered by the clinician to be unfit/not suitable for enrolment in ALPINE
Where this trial is running
London
- University College London Hospitals NHS Foundation Trust — London, United Kingdom (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.