Evaluating nerve damage risk from local anesthesia
Risk of Nerve Damage After Administration of an Inferior Alveolar Nerve Block Using 4% Articaine Versus 2% Lidocaine
This study is testing whether using articaine or lidocaine for dental numbing shots affects the risk of nerve damage in patients.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 55 Years |
| Sex | All |
| Sponsor | Cleveland Dental Institute Academic / other |
| Locations | 2 sites (Akron, Ohio and 1 other locations) |
| Trial ID | NCT06564987 on ClinicalTrials.gov |
What this trial studies
This research evaluates the risk of nerve damage following the administration of two local anesthetics, articaine 4% and lidocaine 2%, during Inferior Alveolar Nerve Block (IANB). In a randomized controlled clinical trial, patients will be assigned to receive either articaine or lidocaine, with the type of anesthetic concealed from the operators and assessors. Participants will be monitored for signs of nerve paresthesia for three months post-procedure to assess any potential nerve injuries.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 18-55 who require an Inferior Alveolar Nerve Block.
Not a fit: Patients with medical conditions, allergies, or those who are pregnant or breastfeeding may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could help identify safer local anesthesia options, reducing the risk of nerve damage for dental patients.
How similar studies have performed: Other studies have explored local anesthetic safety, but this specific comparison of articaine and lidocaine in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients with age between 18-55 years old * Patients need IANB * healthy patient Exclusion Criteria: * medical conditions * allergies * medications * pregnancy and breastfeeding * inability to provide informed consent * specific dental or medical history.
Where this trial is running
Akron, Ohio and 1 other locations
- Cleveland Dental Institute — Akron, Ohio, United States (Recruiting)
- Cleveland Dental Institute — Ashtabula, Ohio, United States (Active_not_recruiting)
Study contacts
- Principal investigator: Waleed Elmallah, PhD — Cleveland Dental Institute
- Study coordinator: Pablo R Velazquez, Resident
- Email: p.velazquez@cdiohio.org
- Phone: 7546108595
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.