Evaluating Nano-Propolis and Nano-Curcumin for Treating Pulp Exposure in Children's Teeth
Clinical And Radiographic Evaluation of Nano-Propolis, Nano-Curcumin and MTA as Direct Pulp Capping Agents in Young Permanant Teeth
This study is testing if nano-propolis and nano-curcumin can help treat children’s teeth with pulp exposure to see if they work better than other treatments.
Quick facts
| Phase | Phase 1 |
|---|---|
| Study type | Interventional |
| Enrollment | 54 (estimated) |
| Ages | 7 Years to 13 Years |
| Sex | All |
| Sponsor | Al-Azhar University Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06029023 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the clinical and radiographic effects of nano-propolis and nano-curcumin as direct pulp capping agents in young permanent teeth with traumatic pulp exposure. Children aged 7 to 13 years with deep carious lesions leading to pulp exposure will be recruited for the trial. Participants will undergo a series of procedures including local anesthesia, cavity preparation, and application of the treatment agents. The effectiveness of these agents will be evaluated based on the formation of a dentin bridge and other clinical outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are children aged 7 to 13 years with traumatic pulp exposure due to carious lesions.
Not a fit: Patients with irreversible pulpitis or other significant dental pathologies will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a novel and effective treatment option for managing pulp exposure in children, potentially improving dental health outcomes.
How similar studies have performed: While the use of nano-particles in dental treatments is emerging, this specific combination of nano-propolis and nano-curcumin as pulp capping agents is relatively novel and has not been extensively tested in previous studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Young permanent teeth with deep carious lesions that led to a caries-exposed pulp after spoon excavation and a diagnosis of reversible pulpitis. * The tooth has a pulp exposure caused by trauma that occurred within 48 h. Exclusion Criteria: * The patient has a history of systemic disease that interferes with pulp healing. * The tooth has clinical signs and symptoms of irreversible pulpitis, e.g., spontaneous throbbing pain, tenderness to percussion, abnormal tooth mobility, swelling, or sinus tract. * Radiographic evidence of internal or external resorption, inter-radicular bone loss, or periapical pathology. * The tooth was non-restorable. During the study, if any symptoms of irreversible pulpitis, apical periodontitis, or infection occurred, the patients received the appropriate treatment following the institute protocol, including regenerative and root canal treatment.
Where this trial is running
Cairo
- Dalia Elasser — Cairo, Egypt (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.