Evaluating Nano Calcium Hydroxide for Treating Infected Tooth Roots
Evaluation of the Antibacterial Potential of Nano Calcium Hydroxide as an Intracanal Medication: A Randomized Clinical Trial
This study is testing a new gel form of Nano Calcium Hydroxide to see if it can better fight bacteria in infected tooth roots compared to traditional treatments for people with tooth infections.
Quick facts
| Phase | Phase2; Phase3 |
|---|---|
| Study type | Interventional |
| Enrollment | 54 (estimated) |
| Ages | 21 Years to 49 Years |
| Sex | All |
| Sponsor | British University In Egypt Academic / other |
| Locations | 1 site (Cairo) |
| Trial ID | NCT06196515 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the antibacterial effectiveness of Nano Calcium Hydroxide as an intracanal medication during the primary endodontic treatment of permanent molars. It involves synthesizing a hydrogel that transforms from liquid to gel at body temperature, which will be compared to both Nano and conventional Calcium Hydroxide in paste form. The study will quantitatively evaluate bacterial reduction by analyzing samples taken from the root canal before and after treatment in patients with apical periodontitis. The goal is to determine the most effective form of calcium hydroxide for improving dental outcomes.
Who should consider this trial
Good fit: Ideal candidates are healthy adults aged 21-49 with a single permanent molar showing signs of apical periodontitis.
Not a fit: Patients who are pregnant, immunocompromised, or have complicated systemic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective treatments for endodontic diseases, reducing infection rates and improving patient outcomes.
How similar studies have performed: Other studies have shown promise in using nano-formulations for antibacterial purposes, suggesting potential success for this novel approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * healthy males and females. * age range between 21-49. * patients with no physical disability or psychological problems. * patients presenting with single permanent molar with signs and/or symptoms of apical periodontitis, and having Periapican index ≥ 2. Exclusion Criteria: * pregnant women. * patients with immune-compromised disease. * patients with complicated systemic diseases. * patients who took antibiotics within a period of 1 month. * patients with known sensitivity to the medicaments or pharmaceuticals used in this study. * Non-restorable teeth including root fractures, and/or advanced periodontal involvement.
Where this trial is running
Cairo
- british university in Egypt - dentistry collage — Cairo, Egypt (Recruiting)
Study contacts
- Study coordinator: Nada T mohamed, bachelor
- Email: pg.nada92140021@bue.edu.eg
- Phone: +21003577451
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.