Evaluating muscle protein changes from exercise and disuse
Evaluating Changes in Skeletal Muscle Protein Synthesis, and the Dynamic Proteome, Following Unilateral Resistance Exercise Training and Single-leg Immobilization
This study tests how resistance exercise and not using your muscles affect muscle protein changes in healthy young women to help find better ways to prevent muscle loss.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 14 (estimated) |
| Ages | 18 Years to 30 Years |
| Sex | Female |
| Sponsor | Queen's University Academic / other |
| Locations | 1 site (Kingston, Ontario) |
| Trial ID | NCT06350591 on ClinicalTrials.gov |
What this trial studies
This study investigates how resistance exercise and periods of disuse affect skeletal muscle protein turnover in healthy young women. It aims to understand the mechanisms behind muscle atrophy and hypertrophy by examining changes in muscle protein synthesis and breakdown in response to exercise and nutritional intake. Participants will undergo interventions involving immobilization and resistance training while their muscle responses are monitored. The findings could lead to improved strategies for preventing muscle loss due to aging, disease, or inactivity.
Who should consider this trial
Good fit: Ideal candidates are healthy females aged 18-30 with a BMI between 18-28 who engage in structured exercise.
Not a fit: Patients with muscular, neurological, respiratory, or metabolic diseases, as well as those with a history of cancer or other significant health issues, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide insights into effective interventions for preventing muscle atrophy and promoting muscle growth in various populations.
How similar studies have performed: Previous studies have shown success in understanding muscle protein dynamics through similar interventions, although this specific approach may offer novel insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Females 18-30 years * BMI between 18-28 kg/m2 * ≥2 days per week of structured exercise * Generally healthy as assessed by medical and physical activity questionnaires * Participants not currently pregnant Exclusion Criteria: * Any muscular, neurological, respiratory, or metabolic disease including diabetes * Any form of cancer currently or in the last 5 years * Bleeding disorders or antiplatelet / anticoagulation therapy * Currently taking fish oils or within the last 6 months * Currently taking any form of steroid or within the last 3 months * Inability to attain magnetic resonance imaging scans * Known irregular responses to physical activity (e.g., shortness of breath, chest pain, dizziness, etc.) * Any current illness * Currently smoking or smoking within the last 6 months * Currently pregnant * Any concurrent medical, psychiatric, or orthopedic condition that, subject to investigators' discernment, would negatively affect the subject's ability to comply with the study requirements
Where this trial is running
Kingston, Ontario
- School of Kinesiology and Health Studies — Kingston, Ontario, Canada (Recruiting)
Study contacts
- Study coordinator: Chris McGlory, PhD
- Email: Chris.McGlory@queensu.ca
- Phone: 613-533-6000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.