Evaluating MRI's Role in Assessing Cognitive Impairment After Moderate Brain Injury
The Value of Multimodal MR Imaging in Cognitive Assessment of Patients With Moderate Traumatic Brain Injury
First Affiliated Hospital Xi'an Jiaotong University · NCT06099210
This study is testing if special MRI scans can help understand how brain injuries affect thinking skills in people with moderate traumatic brain injury.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | First Affiliated Hospital Xi'an Jiaotong University (other) |
| Locations | 1 site (Xi'an, Shaanxi) |
| Trial ID | NCT06099210 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the effectiveness of multimodal MRI imaging in assessing cognitive impairment in patients with moderate traumatic brain injury (TBI). It focuses on analyzing the relationship between white matter structure damage and cognitive function, utilizing various MR scanning techniques alongside neuropsychological assessments. The study will collect data on MR imaging, hematology, stool samples, and cognitive scales to construct a core injury model that predicts cognitive outcomes following moderate brain trauma.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with moderate traumatic brain injury, specifically those with a Glasgow Coma Scale score between 9 and 12.
Not a fit: Patients with a history of substance abuse, previous traumatic brain injuries, or other neurological disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic methods and treatment strategies for cognitive impairments resulting from moderate traumatic brain injuries.
How similar studies have performed: Other studies have shown promise in using advanced imaging techniques for assessing brain injuries, indicating that this approach may yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * GCS 9-12 points * Time for loss of consciousness: 30 minutes-24 hours * Forget time after injury: 1-7 days Exclusion Criteria: * Alcohol consumption, substance abuse during or within the previous 24 hours * Previous history of traumatic brain injury, MRI contraindication, penetrating brain injury, psychotropic substance use, spinal cord injury, positive neurological examination, multifunctional disorder * Neurological and psychiatric history
Where this trial is running
Xi'an, Shaanxi
- The First Affiliated Hospital of Xi'an Jiaotong University — Xi'an, Shaanxi, China (RECRUITING)
Study contacts
- Study coordinator: Zhuonan Wang, PHD
- Email: wangzhuonan@xjtu.edu.cn
- Phone: 15332359525
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Brain Injuries, moderate traumatic brain injury, MRI, axial cord injury, cognitive disorder