Evaluating microvascular resistance in heart transplant patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the index of microvascular resistance (IMR) in heart transplant patients to determine its effectiveness in reducing the need for endomyocardial biopsies (EMB). By measuring IMR, coronary flow reserve (CFR), and fractional flow reserve (FFR) within the first two months and one year post-transplant, the study seeks to improve patient care and minimize complications associated with repeated EMBs. The study will involve multiple centers and will include stable heart transplant patients who provide informed consent.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Heart transplant patients \>18 years.
* Patients who have received and signed informed consent.

Exclusion Criteria:

* Patients with hemodynamic instability after HT, including cardiogenic shock or severe coagulopathy.
* Patients with acute cellular rejection before intracoronary physiological assessment.
* Patients with bronchial asthma or bronchopathy with a positive bronchodilation test, which contraindicates the use of adenosine.
* Patients with epicardial coronary lesions with a resting physiological index ≤0.89 or ≤0.80 at hyperemia.
* Patients unlikely to cooperate or with inability or unwillingness to give informed consent.

Where it's running

• Hospital Miguel Servet
  Zaragoza, Zaragoza, Spain Recruiting
• Hospital Universitario de Bellvitge
  L'Hospitalet de Llobregat, Barcelona, Spain Active not recruiting

Study contacts

• Study coordinator: Georgina Fuertes, MD PHD
• Email: georginaff@hotmail.com
• Phone: 0034 976765500

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Nationwide Swedish program testing donor-derived cell-free DNA to monitor rejection after heart transplant

  This project tests whether a blood test measuring donor-derived cell-free DNA can help monitor rejection in adults who have had a heart transplant.

  Recruiting Karolinska Institutet · Stockholm · NCT07531784

• Using mobile video to help young heart transplant patients take their medications

  This study tests whether using mobile videos can help young heart transplant patients remember to take their medications regularly.

  Recruiting at 3 sites University of Florida · Coral Gables, Florida and 3 other locations · NCT05732779

• Evaluating donor-derived DNA levels in heart transplant rejection

  This study is testing whether measuring donor DNA in the blood can help doctors better understand and detect heart transplant rejection in patients who are already having biopsies.

  Recruiting at 9 sites University of Alberta · Little Rock, Arkansas and 11 other locations · NCT04707872

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.