Evaluating Macitentan for treating coronary microvascular angina

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to assess the efficacy of Macitentan, an endothelin receptor antagonist, in patients suffering from coronary microvascular angina, a condition that significantly impacts quality of life and is currently without effective treatments. Participants aged 18-75 with typical angina symptoms and specific coronary microcirculatory dysfunction will receive a daily dose of Macitentan. The study will focus on evaluating improvements in symptoms and coronary microvascular function, addressing limitations of previous trials that relied on conventional angiography. The study seeks to provide a more direct assessment of treatment effects on microvascular function.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-75 years old.
* With typical angina symptoms.
* Excluding obstructive coronary lesions (coronary stenosis ≤50% or FFR ≥0.8) by CAG.
* Coronary microcirculatory function CFR\<2.5 and/or IMR\>25 assessed by temperature dilution method.

Exclusion Criteria:

* Pregnant or lactating women.
* History of heart attack within the last 90 days.
* Severe heart disease (e.g., moderate to severe heart failure, severe heart valve disease).
* Severe renal impairment (GFR \<30 ml/min/1.73m2).
* Severe liver disease (Child-Pugh class C).
* Moderately severe anaemia (haemoglobin concentration \<90 g/L).
* Participation in another drug intervention trial study within the last 90 days.

Where it's running

• China-Japan Friendship Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Study coordinator: Yanxiang Gao, Study Principal Investigator
• Email: gaoyx1980@163.com
• Phone: +86 13811020048

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.