Evaluating lung volume reduction using dual-energy CT scans
LUng voluMe reductIoN by DuAl ENergy CT Evaluation (LUMINANCE) Study
This study is testing if dual-energy CT scans can give helpful information for adults with emphysema who are getting a lung procedure to improve their breathing.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospitals Cleveland Medical Center Academic / other |
| Locations | 1 site (Cleveland, Ohio) |
| Trial ID | NCT05816239 on ClinicalTrials.gov |
What this trial studies
This observational study aims to determine the effectiveness of dual-energy CT scans in providing valuable information for patients undergoing bronchoscopic lung volume reduction for emphysema. Up to 30 adult participants will be enrolled at University Hospitals Cleveland Medical Center, where they will receive the valve placement procedure. The study focuses on assessing lung perfusion through advanced imaging techniques to enhance treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with emphysema who are suitable for bronchoscopic lung volume reduction.
Not a fit: Patients who are unable to provide consent, pregnant or nursing women, and those with contraindications to dual-energy CT scans will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the precision of lung volume reduction procedures, leading to better patient outcomes.
How similar studies have performed: While this approach is innovative, similar studies using advanced imaging techniques have shown promise in enhancing procedural outcomes.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients (≥ 18 years of age at the time of written informed consent) with emphysema who have been deemed appropriate candidates for bronchoscopic lung volume reduction Exclusion Criteria: * Patients unable to provide consent * Patients who are pregnant or nursing * Women of child-bearing age will undergo pregnancy tests based on University Hospital (UH) standard bronchoscopy pre-procedural testing * Patients unable to undergo a DECT chest (contraindications to a CT chest with intravenous contrast such as a reported or documented allergy to intravenous (IV) contrast or impaired renal function, defined as the following: * Glomerular filtration rate (GFR) \<90 ml/min/1.73 m2 at the time of initial evaluation if patient age is ≤ 59 years * GFR \<85 ml/min/1.73 m2 if patient age is 60-69 years * GFR \<75 ml/min/1.73 m2 if patient age is ≥70 years
Where this trial is running
Cleveland, Ohio
- University Hospitals Cleveland Medical Center — Cleveland, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Sameer Avasarala, MD — University Hospitals
- Study coordinator: Jennie Pexa, RN
- Email: Jennie.Pexa@UHhospitals.org
- Phone: 216-844-2381
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.