Evaluating low-concentration iodine contrast in chest CT imaging
Chest CT Using Low-concentration Iodine Contrast Media - a Prospective Multicenter Comparative Study
This study tests whether using less iodine contrast in chest CT scans can still give clear images while being safer for patients.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 370 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | Seoul St. Mary's Hospital Academic / other |
| Locations | 6 sites (Bucheon-si, Gyeonggi-do and 5 other locations) |
| Trial ID | NCT05967117 on ClinicalTrials.gov |
What this trial studies
This study evaluates the image quality of chest CT scans using low-concentration iodine contrast agents at low tube voltage. It aims to compare the effectiveness of these agents against conventional iodine concentrations and voltages. The primary focus is on optimizing CT protocols to enhance image quality while potentially reducing the amount of iodine contrast used. The study involves patients who are undergoing contrast-enhanced chest CT scans and assesses various combinations of iodine concentrations and tube voltages.
Who should consider this trial
Good fit: Ideal candidates are adults aged 19 years or older, weighing less than 90 kg, and with a BMI under 30 who require a contrast-enhanced chest CT.
Not a fit: Patients under 18, those with heart failure, pregnancy, or a history of hypersensitivity to iodine-based drugs may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved imaging techniques that enhance diagnostic accuracy while minimizing iodine exposure for patients.
How similar studies have performed: Other studies have explored similar approaches in optimizing CT imaging protocols, indicating potential for success in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 19 years or older, weighing less than 90 kg, and BMI less than 30 who underwent contrast-enhanced chest CT alone Exclusion Criteria: 1. Under the age of 18 2. Cases where contrast-enhanced CT cannot be performed 3. Heart failure 4. Pregnancy 5. If patients cannot voluntarily give written consent to participate in this clinical trial 6. In the case of an anatomical deformation that may interfere with image analysis in the previous image 7. Patients with a history of hypersensitivity to IOBRIX, components of IOBRIX, and iodine-based drugs 8. Patients with severe thyroid disease (Iodine may accumulate in the thyroid gland and worsen symptoms.) 9. Those who are judged unsuitable by the tester for other reasons Patients aged 19 years or older, weighing less than 90 kg, and BMI less than 30 who underwent contrast-enhanced chest CT alone
Where this trial is running
Bucheon-si, Gyeonggi-do and 5 other locations
- Bucheon St. Mary's Hospital, The Catholic University of Korea — Bucheon-si, Gyeonggi-do, South Korea (Completed)
- Pusan National University Yangsan Hospital — Yangsan, Gyeongsangnam-do, South Korea (Recruiting)
- Jeonbuk National University Hospital — Jeonju, Jeollabuk-do, South Korea (Recruiting)
- Seoul St. Mary's Hospital, The Catholic University of Korea — Seoul, Seocho-gu, South Korea (Recruiting)
- Chonnam National University Hospital — Gwangju, South Korea (Completed)
- Seoul National University Hospital — Seoul, South Korea (Completed)
Study contacts
- Study coordinator: Jung IM Jung, MD, PhD
- Email: jijung@catholic.ac.kr
- Phone: +822-2258-1456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.