Evaluating long-term outcomes of stereotactic radiotherapy for ventricular tachycardia
Official title: Cardiac RadiothErapy for VEntricular Tachycardia II - a Prospective Observational Cohort Study
Run by Universitaire Ziekenhuizen KU Leuven · NCT06744530 · Data updated 2026-11-12
This study is testing if a special type of radiation treatment can help people with hard-to-treat ventricular tachycardia feel better and stay safe over the long term.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Universitaire Ziekenhuizen KU Leuven Academic / other |
| Locations | 1 site (Leuven) |
| Status | Recruiting |
| Started | January 1, 2025 |
| Main results expected | December 2033 |
| Study ends | December 2034 |
| Registry record updated | April 29, 2026 |
| Trial ID | NCT06744530 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are patients with therapy-refractory ventricular tachycardia who are eligible for stereotactic radiotherapy based on a multidisciplinary evaluation.
✕Probably not a fit
Patients who may not benefit from this study include those with contraindications for STAR, such as pregnancy, previous cardiac radiotherapy, or a life expectancy of less than six months without VT.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to assess the long-term efficacy and safety of stereotactic radiotherapy ablation (STAR) in patients suffering from therapy-refractory ventricular tachycardia (VT). By focusing on patients who are eligible for STAR based on a multidisciplinary discussion, the study seeks to fill the gap in knowledge regarding the long-term outcomes of this treatment approach. Participants will be monitored for their responses and any adverse effects following the intervention, contributing valuable data to the field of cardiac care.
Why it matters
Potential benefit: If successful, this study could provide critical insights into the long-term effectiveness and safety of STAR for patients with refractory ventricular tachycardia.
How similar studies have gone: While stereotactic radiotherapy has become a standard care option, this study aims to provide new insights into its long-term outcomes, indicating a novel approach in this specific context.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eligible for STAR for therapy-refractory VT based on a multidisciplinary discussion * Ability to give a written informed consent and willingness to return for follow-up Exclusion Criteria: * Contra-indications for STAR, including pregnancy or breastfeeding, previous radiotherapy with cardiac involvement, life-expectancy \< 6 months in the absence of VT * Any condition that is deemed a contraindication in the judgment of the investigators
Where it's running
-
UZ Leuven
Leuven, Belgium Recruiting
Study contacts
- Study coordinator: Bert Vandenberk, MD PhD
- Email: bert.vandenberk@uzleuven.be
- Phone: +3216338686
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Risk of malignant arrhythmias after acute coronary syndrome
This study tracks how often dangerous heart rhythms occur in adults admitted for ACS and looks for patterns that might predict them.
-
Targeted ablation to block scar channels that cause ventricular tachycardia
This study tests whether targeted radiofrequency ablation of scar-channel exits can prevent ventricular tachycardia in patients with scarred hearts.
-
Predict Arrhythmia Risk with Intelligent Software
Researchers are testing AI-powered predictions to see if clinicians can spot patients at risk for dangerous heart rhythms using bedside ECG data.
-
Severe Complications During VT/PVC Ablation
This study looks at real-world cases to see what severe complications occur during VT or PVC ablations and how patients are managed afterward.
-
Non-invasive mapping to help treat ventricular tachycardia due to heart disease
This study tests a non-invasive mapping tool to guide VT ablation in adults with structural heart disease and prior heart attack.
-
Personalised VT substrate mapping with dynamic voltage mapping during ablation
A procedure study to see if using dynamic voltage mapping during VT ablation helps identify and treat scar-related electrical circuits in people with ventricular tachycardia.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.