Evaluating long-lasting insecticidal nets for malaria prevention in Uganda
LLIN Evaluation in Uganda Project (LLINEUP3): Impact of Long-lasting Insecticidal Nets (LLINs) Treated With Chlorfenapyr Plus Pyrethroid vs LLINs Treated With Piperonyl Butoxide Plus Pyrethroid on Malaria Incidence in Uganda: a Cluster-randomised Trial
This study is testing whether two different types of treated mosquito nets can help reduce malaria cases in Uganda.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 215903 (estimated) |
| Sex | All |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (Kampala) |
| Trial ID | NCT05950191 on ClinicalTrials.gov |
What this trial studies
This project aims to evaluate the effectiveness of two types of long-lasting insecticidal nets (LLINs) in reducing malaria incidence in Uganda. The trial will distribute LLINs treated with either chlorfenapyr-pyrethroid or PBO-pyrethroid to households as part of a nationwide campaign. A total of 24 clusters across 20 districts will be randomized to receive one of the two LLIN types, and the impact will be assessed through health facility surveillance, community surveys, and entomology surveys over a two-year period. The primary outcome will focus on malaria incidence rates in the participating areas.
Who should consider this trial
Good fit: Ideal candidates for this study include households in Uganda with at least one adult resident who can provide informed consent.
Not a fit: Patients living in households that are vacant or have been destroyed will not benefit from this study.
Why it matters
Potential benefit: If successful, this initiative could significantly reduce malaria incidence and improve public health in Uganda.
How similar studies have performed: Previous studies have shown success with similar LLIN distribution campaigns, indicating a promising approach to malaria prevention.
Eligibility criteria
Show full inclusion / exclusion criteria
Household Survey Inclusion Criteria: 1. At least one adult aged 18 years or older present 2. Adult is a usual resident who slept in the sampled household on the night before the survey 3. Agreement of the adult resident to provide informed consent for the household and entomology survey Exclusion Criteria: 1. Dwelling destroyed or not found 2. Household vacant 3. No adult resident home on more than 3 occasions Clinical Survey Inclusion Criteria: 1. Usual resident who was present in the sampled household on the night before the survey 2. Agreement of adult or parent/guardian (of children) to provide informed consent 3. Agreement of child aged 8 years or older to provide assent Exclusion Criteria: 1. Resident not home on day of survey
Where this trial is running
Kampala
- Infectious Diseases Research Collaboration — Kampala, Uganda (Recruiting)
Study contacts
- Principal investigator: Moses Kamya, MBChB, MMed, PhD — Makerere University; Infectious Diseases Research Collaboration
- Study coordinator: Grant Dorsey, MD, PhD
- Email: grant.dorsey@ucsf.edu
- Phone: 628-206-4680
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.