Evaluating kidney injury risk in stroke patients after thrombectomy
CAN-REST: Contrast-Associated Nephropathy Risk Evaluation in Acute Ischemic Stroke After Endovascular Thrombectomy
This study looks at whether stroke patients who have a specific procedure to remove blood clots are at risk for kidney injury from the contrast dye used and how this affects their recovery and hospital stay.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 8000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Niguarda Hospital Academic / other |
| Locations | 1 site (Milano, Lombardia) |
| Trial ID | NCT06596603 on ClinicalTrials.gov |
What this trial studies
The CAN-REST study is a multicenter, observational, and retrospective analysis focused on patients with acute ischemic stroke who undergo endovascular thrombectomy. It aims to evaluate the incidence of contrast-associated acute kidney injury (CA-AKI) and identify risk factors contributing to its development. The study will also assess the impact of CA-AKI on clinical outcomes, including hospital stay length, functional recovery, and mortality rates. By analyzing data from multiple centers across Italy, Europe, the USA, and Canada, the study seeks to develop predictive models to improve patient management and outcomes.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old who have experienced an acute ischemic stroke and are treated with endovascular thrombectomy.
Not a fit: Patients on chronic dialysis will not benefit from this study as they will be excluded from the analyses.
Why it matters
Potential benefit: If successful, this study could lead to better risk assessment and management strategies for preventing kidney injury in stroke patients undergoing thrombectomy.
How similar studies have performed: Other studies have shown success in evaluating risk factors for acute kidney injury in similar patient populations, indicating that this approach is supported by existing research.
Eligibility criteria
Show full inclusion / exclusion criteria
To be eligible to participate in this study, subjects must meet all of the following criteria: * Age \>18 years at the time of AIS * Documented serum creatinine: * pre-EVT and * within 48h and/or within 7 days after EVT. Patients on chronic dialysis will be collected but excluded from the analyses
Where this trial is running
Milano, Lombardia
- ASST Grande Ospedale Metropolitano Niguarda — Milano, Lombardia, Italy (Recruiting)
Study contacts
- Study coordinator: Ghil Schwarz, MD
- Email: ghil.schwarz@ospedaleniguarda.it
- Phone: 0039026444
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.