Evaluating JAB-21822 for advanced lung cancer with specific mutations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety, tolerability, and clinical activity of JAB-21822 in patients with advanced or metastatic non-small cell lung cancer (NSCLC) characterized by KRAS p.G12C and STK11 co-mutations. The trial consists of a Dose Escalation phase to assess safety and a subsequent Expansion phase to evaluate preliminary antitumor activity in treatment-naïve patients or those who have received at least one prior therapy. Participants will undergo molecular testing to confirm their eligibility based on specific genetic mutations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Pathologically documented, locally-advanced or metastatic NSCLC with KRAS p.G12C mutation identified through molecular testing.
2. STK11 co-mutation and KEAP1 Wild-Type (local confirmation)
3. Treatment naïve or have received at least 1 prior standard therapy for advanced NSCLC
4. ECOG 0-1

Exclusion Criteria:

1. Has CNS metastases or carcinomatous meningitis, except treated CNS metastases with no evidence of radiographic progression or hemorrhage for at least 28 days
2. Any severe and/or uncontrolled medical conditions
3. Active infection requiring systemic treatment within 7 days
4. Therapeutic radiation therapy within 3 weeks of study day 1

Where it's running

• Research site01
  Beijing, Beijing Municipality, China Recruiting
• Research site08
  Beijing, Beijing Municipality, China Not yet recruiting
• Research site09
  Beijing, Beijing Municipality, China Not yet recruiting
• Research site021
  Beijing, Beijing Municipality, China Not yet recruiting
• Research site02
  Beijing, Beijing Municipality, China Not yet recruiting
• Research site013
  Beijing, Beijing Municipality, China Not yet recruiting

Study contacts

• Study coordinator: Shanghai Allist Pharmaceuticals Co., Ltd Shanghai Allist Pharmaceuticals Co., Ltd
• Email: zhenhua.gong@allist.com.cn
• Phone: 021-80423288

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.