Evaluating imaging techniques for atrial fibrillation ablation
Contribution of Left Atrial Epicardial Fat Quantification by Computed Tomography and Left Atrial Strain by MRI in Atrial-Fibrilation Ablation: "The CTStrain-AF Study"
This study is testing new imaging techniques to see if measuring heart fat can help doctors choose the best patients for their first atrial fibrillation ablation to improve treatment success.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 130 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Assistance Publique - Hôpitaux de Paris Academic / other |
| Locations | 1 site (Paris) |
| Trial ID | NCT04281329 on ClinicalTrials.gov |
What this trial studies
This study aims to assess the prognostic value of new automated measurement techniques for intra-myocardial atrial fat using cardiac CT and global left atrial strain through MRI in patients scheduled for their first atrial fibrillation (AF) ablation. It seeks to improve patient selection for AF ablation by identifying predictive factors that could enhance the success rates of the procedure. The study is prospective and multicenter, involving multiple hospitals to gather a diverse patient cohort. By analyzing the relationship between left atrial fat volume and ablation outcomes, the study hopes to provide insights into optimizing AF treatment.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are scheduled for their first radiofrequency AF ablation within the next six months.
Not a fit: Patients who have previously undergone AF ablation or those scheduled for cryoablation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better patient selection for AF ablation, potentially increasing the success rates of the procedure.
How similar studies have performed: While previous studies have explored the use of MRI for predicting AF ablation outcomes, the specific combination of imaging techniques in this study is novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient in whom radiofrequency AF ablation is scheduled within the next 6 months. * age ≥18 years * Patient affiliated to a social security scheme * Patient informed and given written consent for participation in the study. Exclusion Criteria: * Refusal to participate in the study * Patient who has already benefited from an AF ablation procedure * Patient for whom an AF ablation procedure by cryoablation system is planned * Scanner or MRI pre-inclusion not exploitable * Presence of an implantable cardiac prosthesis of pacemaker type or defibrillator * Claustrophobia * Iodinated / gadolinium contrast medium allergy * Chronic renal failure with clearance \<30ml / min * Follow-up visits not possible * Pregnancy in progress * Patients unable to sign consent * Minors and adults protected under legal protection (tutorship or guardianship) * Period of exclusion from a research study
Where this trial is running
Paris
- Centre Hospitalier Universitaire Pitie-Salpetriere — Paris, France (Recruiting)
Study contacts
- Study coordinator: Estelle GANDJBAKHCH, MD, PhD
- Email: estelle.gandjbakhch@aphp.fr
- Phone: 01 42 16 30 55
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.