Evaluating if global strain and mechanical dispersion can better predict death and arrhythmias than ejection fraction in heart failure patients
Improved Prediction of Clinical Outcome With the Use of Global Strain and Mechanical Dispersion in Patients With Myocardial Infarction and Heart Failure
This study is testing if new heart measurements can better predict serious heart problems and death in patients with heart failure than the usual method.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Oslo University Hospital Academic / other |
| Locations | 8 sites (Prague and 7 other locations) |
| Trial ID | NCT02286908 on ClinicalTrials.gov |
What this trial studies
This observational study aims to determine whether global strain and mechanical dispersion measurements can more accurately predict mortality and ventricular arrhythmias compared to traditional left ventricular ejection fraction in patients with myocardial infarction and heart failure. The study will involve patients who are planned for primary prophylactic internal cardioverter defibrillator implantation and will utilize transthoracic echocardiography for data collection. Participants will be followed for a period of 3 to 5 years to assess outcomes related to heart function and arrhythmias.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years old with a history of myocardial infarction and heart failure who are planned for an internal cardioverter defibrillator.
Not a fit: Patients without myocardial infarction or heart failure symptoms, or those not planned for an internal cardioverter defibrillator, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk stratification and management of patients with heart failure, potentially reducing mortality and arrhythmia rates.
How similar studies have performed: Other studies have explored similar predictive measures, but this specific approach focusing on global strain and mechanical dispersion in this patient population is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All patients with 1. myocardial infarction 2. heart failure( defined as heart failure symptoms: reduced left ventricular function/ and or heart failure signs on chest x ray. 3. planned for primary prophylactic ICD * over 18 years of age * Informed consent Exclusion Criteria: -
Where this trial is running
Prague and 7 other locations
- Vseobecna fakultni nemocnice Praha/ Prague General hospital — Prague, Czechia (Recruiting)
- Sørlandet sykehus HF — Arendal, Agder, Norway (Recruiting)
- Vestre Viken HF — Drammen, Norway (Recruiting)
- Sørlandet sykehus Kristiansand — Kristiansand, Norway (Recruiting)
- Oslo university hospital — Oslo, Norway (Recruiting)
- Sykehuset Telemark HF — Skien, Norway (Recruiting)
- Stavanger universitetssjukehus — Stavanger, Norway (Recruiting)
- Universitetssykehuset Nord Norge, Tromsø — Tromsø, Norway (Recruiting)
Study contacts
- Study coordinator: Thor Edvardsen, MD, PHD
- Email: thor.edvardsen@medisin.uio.no
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.