Evaluating Huaier Granule for Postoperative Treatment of Pancreatic Cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter, prospective clinical study aims to assess the efficacy and safety of Huaier Granule as a postoperative adjuvant treatment for patients with resectable pancreatic cancer. Participants will be divided into two groups: one receiving standard chemotherapy and the other receiving Huaier Granule exclusively. The study plans to enroll at least 642 subjects who have undergone radical tumor resection and have been diagnosed with pancreatic adenocarcinoma. The trial will take place from April 2024 to March 2026 across selected research centers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age range from 18 to 80 years old, regardless of gender;
* Pancreatic cancer was diagnosed by histopathology after radical surgery within 12 weeks before enrollment;
* Did not receive neoadjuvant therapy before surgery and did not receive any adjuvant therapy after surgery;
* ECOG score 0-3 points;
* Those who choose to use standard chemotherapy independently based on their own situation, or choose Huaier granules for subsequent treatment, voluntarily participate in and cooperate with various research work, including but not limited to cooperating with treatment and follow-up, cooperating with researchers for data collection, and not actively taking other treatments.
* The subjects voluntarily signed a written informed consent form before participating in this study.

Exclusion Criteria:

* Known to be allergic to the components of Huaier granules or to avoid or use Huai er granules with caution (Huaier group);
* Difficulties in taking oral medication due to active gastrointestinal bleeding, perforation, gastric paralysis, etc;
* Suffering from serious mental illness or other reasons that the researcher deems unsuitable to participate in this study.
* History of merging with other malignant tumors;
* Patients with concomitant myocardial infarction, cerebral infarction, and other thromboembolic diseases requiring surgical treatment;
* Concomitant severe infection;
* Child Pugh C-grade liver function, renal function 2-5 grades (glomerular filtration rate\<90ml/min);
* Pregnant or lactating women or those planning to conceive;
* The patient has received other traditional Chinese patent medicines and simple preparations with anti-tumor effect, chemotherapy or physical therapy in the past 4 weeks(including but not limited to compound cantharidin capsules, cinobufotalin capsules, Kangai injection, please refer to the drug instructions for details).

Where it's running

• Zheng Wang
  Xi'an, Shannxi, China Recruiting

Study contacts

• Principal investigator: Zheng Wang, PhD — First Affiliated Hospital Xi'an Jiaotong University
• Study coordinator: Zheng Wang, PhD
• Email: zheng.wang11@mail.xjtu.edu.cn
• Phone: +8615902993665

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Chronic Stress and Pancreatic Cancer Outcomes in People with Pancreatic Cancer

  This study tests whether ongoing psychological stress affects how pancreatic cancer behaves and responds to treatment in adults.

  Recruiting Shanghai Zhongshan Hospital · Changsha, Hunan and 2 other locations · NCT07529626

• Neoadjuvant chemotherapy versus immediate surgery for resectable pancreatic head and periampullary cancer

  This trial tests if giving chemotherapy before surgery helps people with resectable pancreatic head or periampullary cancer live longer than having immediate surgery followed by chemotherapy.

  Recruiting Phase 3 Minia University · Minya, Minya Governorate · NCT07081360

• Improving recovery after pancreatic surgery

  This study is testing if a special recovery program can help people recover better and faster after surgery for pancreatic cancer compared to standard care.

  Recruiting University of Thessaly · Larissa · NCT06935448

• Antecolic versus Retrocolic Gastrojejunostomy after a Whipple (pancreaticoduodenectomy)

  This trial tests whether routing the stomach-to-small-intestine connection in front of (antecolic) or behind (retrocolic) the colon changes the chance of delayed gastric emptying in adults having a Whipple operation for pancreatic cancer.

  Recruiting University of Thessaly · Larissa · NCT06914349

• Evaluating pain management methods for minimally invasive cancer surgery

  This study is testing which pain management method works best for people undergoing minimally invasive cancer surgery by comparing three different approaches.

  Recruiting Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · Pittsburgh, Pennsylvania · NCT06731998

• Nimotuzumab with nab-paclitaxel and gemcitabine for EGFR-positive pancreatic cancer

  This study is testing if a new combination of Nimotuzumab with nab-paclitaxel and gemcitabine can help people with EGFR-positive pancreatic cancer live longer and stay cancer-free after surgery.

  Recruiting Phase 2 Zhejiang Provincial People's Hospital · Hangzhou, Zhejiang · NCT06722911

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.