Evaluating how prone ventilation affects blood flow in ARDS patients
Evaluate the Effect of Prone Ventilation on Ventilated-blood Flow Ratio in Patients With Acute Respiratory Distress Syndrome by Electrical Impedance Tomography
This study tests if lying face down helps improve blood flow and lung function in patients with Acute Respiratory Distress Syndrome (ARDS) who are on a ventilator.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 90 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Wuhan Union Hospital, China Academic / other |
| Locations | 1 site (Wuhan, Hubei) |
| Trial ID | NCT06181539 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the effects of prone ventilation on the ventilated-blood flow ratio in patients suffering from Acute Respiratory Distress Syndrome (ARDS). It aims to understand how this positioning can improve lung function and oxygenation in patients who are mechanically ventilated. The study will utilize Electrical Impedance Tomography (EIT) to assess changes in ventilation and perfusion dynamics. By analyzing the outcomes of patients with ARDS, the research seeks to identify which individuals benefit most from this intervention.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who are intubated and mechanically ventilated in a prone position due to ARDS.
Not a fit: Patients with contraindications for EIT or those with unstable medical conditions, such as severe lung disease or recent major surgeries, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment protocols for ARDS, potentially reducing mortality rates.
How similar studies have performed: Previous studies have shown varying success with prone ventilation in ARDS patients, indicating that while it can improve oxygenation, responses can differ significantly among individuals.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1. Age ≥18 years. 2. ARDS patients with endotracheal intubation and mechanical ventilation in prone position Exclusion Criteria: * 1. Contraindications of EIT such as chest wound dressing, installation of pacemaker, defibrillator, etc. 2. Unstable vertebral fracture 3. Within 15 days after severe facial trauma or facial surgery 4 within 15 days after tracheal surgery or sternotomy 5. Hemodynamic instability or recent cardiac arrest 6. Increased intraocular pressure. 7. Unstable femoral or pelvic fractures and pelvic external fixation. 8 He had severe chest wall disease and unstable rib fractures. 9 Recent cardiothoracic surgery. 10. Pneumothorax 11. Chronic lung disease: severe obstructive pulmonary disease, severe asthma, interstitial lung disease. 12. Maternal 13. Extracorporeal membrane oxygenation(ECMO) had been administered on admission to the ICU. 14. Intracranial hypertension 15. Pulmonary embolism, acute or chronic right heart failure 16. Severe cardiac dysfunction (New York Heart Association class III or IV, acute coronary syndrome, or sustained ventricular tachyarrhythmia), cardiogenic shock; 17. No informed consent was obtained
Where this trial is running
Wuhan, Hubei
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology — Wuhan, Hubei, China (Recruiting)
Study contacts
- Principal investigator: Xiaojing zou, MD — Wuhan Union Hospital, China
- Study coordinator: Yongran Wu, MD
- Email: 974528836@qq.com
- Phone: 027-85351606
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.