Evaluating how platelet-rich fibrin affects tooth movement in orthodontics
Evaluation of Effect of Platelet-Rich Fibrin on Orthodontic Tooth Movement: a Split Mouth Randomised Controlled Trial
This study tests if using platelet-rich fibrin can speed up tooth movement for people getting braces who need certain teeth removed.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Enrollment | 15 (estimated) |
| Ages | 18 Years to 45 Years |
| Sex | All |
| Sponsor | Dow University of Health Sciences Academic / other |
| Locations | 1 site (Karachi, Sindh) |
| Trial ID | NCT06634017 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the impact of platelet-rich fibrin (PRF) on the rate of tooth movement in orthodontic patients. It employs a split-mouth randomized controlled design, allowing for direct comparison within the same patient. The study focuses on patients undergoing orthodontic treatment requiring upper first premolar extraction and canine retraction, with a specific emphasis on a larger sample size from the Pakistani population. The trial aims to provide insights into how PRF can enhance orthodontic outcomes.
Who should consider this trial
Good fit: Ideal candidates are orthodontic patients with good oral hygiene who require upper first premolar extraction and canine retraction.
Not a fit: Patients who are smokers, have health complications, or have a history of certain medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to faster and more effective orthodontic treatments for patients.
How similar studies have performed: While the use of platelet-rich fibrin in various medical fields has shown promise, this specific application in orthodontics is relatively novel and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients who give written consent to participate in the research * Orthodontic patients with good oral hygiene * Patients with periodontal probing depths≤3 mm with no bone loss * Patients undergoing orthodontic treatment with fixed appliance and requiring upper first premolar extraction followed by canine retraction * Patients treated with canine retraction utilizing maximum anchorage in the maxillary arch from trans-palatal arch anchorage device * Patients with mild to moderate crowding in maxillary arch * Patients with no previous history of orthodontic treatment Exclusion Criteria: * patients who are smokers, health compromised (such as diabetics, with bone disorders, immunocompromised, known with blood dyscrasias) will be excluded from the trial. Patients with drug history of non-steroidal anti-inflammatory drugs, anti-inflammatory (in last 30 days), antibiotic therapy in last 3 months and those women who are pregnant will also be excluded. Other exclusion criteria will be patients with hypodontia, impacted/ectopic canines, extracted first molars, and patients who may discontinue the trial with or without assigning any reasons and those not consenting to participate in the research.
Where this trial is running
Karachi, Sindh
- Dow university of health sciences — Karachi, Sindh, Pakistan (Recruiting)
Study contacts
- Study coordinator: Fahad Iqbal Farooqui, bds
- Email: fahad.iqbal@duhs.edu.pk
- Phone: 021-111113847
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.