Evaluating how oregano affects drug metabolism

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to investigate the impact of oregano on the pharmacokinetics of pharmaceutical drugs. By utilizing a drug cocktail approach, the study will assess how oregano supplements may influence the activity of key drug-metabolizing enzymes, particularly cytochrome P450 enzymes. Healthy participants aged 18-64 will be recruited, and they will need to abstain from various substances that could interfere with the study. The findings could provide insights into potential drug interactions caused by oregano consumption.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Between 18-64 years old and healthy
* Not taking any medications (prescription and non-prescription) or dietary/herbal supplements that can interfere with study drug pharmacokinetics
* Willing to abstain from consuming dietary/herbal supplements and citrus juices for several weeks
* Willing to abstain from cannabis/marijuana, hemp, and THC- and CBD-containing products for several weeks
* Willing to abstain from consuming caffeinated beverages or other caffeine-containing products the evening before and the morning of the first day of each study arm
* Willing to abstain from consuming any alcoholic beverages for at least 1 day prior to any study day and during the study day
* Willing to use a secondary method of birth control that does not include the introduction or discontinuance of hormonal-based birth control (such as abstinence, copper IUD, or condoms). Specifically, regardless of the use hormonal-based birth control, a non-hormonal method should be used for the duration of the study and for three weeks following cessation of participation.
* Willing to abstain from consuming oregano (as a food additive or otherwise) for the duration of the study
* Geographically located within a 40-mile radius of Spokane and have the time to participate

Exclusion Criteria:

* Under 18 or over 64 years old
* Taking medications or dietary/herbal supplements that can interfere with study drug pharmacokinetics
* Have a major illness
* Taking medication/supplements for a mineral deficiency
* History of intolerance or allergy to oregano or any of the cocktail drugs (caffeine, dextromethorphan, losartan, midazolam, and omeprazole)
* Use of cannabis/marijuana, hemp, and CBD- and/or THC-containing products within the last month
* Currently using drugs or illicit substances for recreational purposes
* Pregnant or nursing
* Geographically located outside the 40-mile radius of Spokane and do not have the time to participate
* Cannot read and speak English

Where it's running

• Washington State University College of Pharmacy and Pharmaceutical Sciences
  Spokane, Washington, United States Recruiting

Study contacts

• Study coordinator: Mary F Paine, RPh, PhD
• Email: mary.paine@wsu.edu
• Phone: 509-358-7759

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.