Evaluating how obesity affects pancreatic cancer in minority populations
Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations
This study is trying to see how obesity affects the development of pancreatic cancer in African American and Non-Hispanic White adults to find better ways to treat it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 125 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | H. Lee Moffitt Cancer Center and Research Institute Academic / other |
| Locations | 2 sites (Tampa, Florida and 1 other locations) |
| Trial ID | NCT05687188 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate the mechanisms by which obesity contributes to pancreatic cancer development in minority populations, specifically African American and Non-Hispanic White adults. Participants will be recruited from gastrointestinal clinics and will undergo blood and tissue sample collection, as well as medical imaging. The study seeks to identify unique biological profiles associated with pancreatic tumors and adipose tissue dysfunction, with the goal of predicting therapeutic responses and targeting obesity-related pathways in pancreatic cancer progression. The research will utilize a multidisciplinary approach involving in vitro, ex vivo, and in vivo techniques.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who self-identify as African American or Non-Hispanic White and have a clinical suspicion or diagnosis of pancreatic cancer.
Not a fit: Patients under 18 years of age or those without a suspicion or diagnosis of pancreatic cancer will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and treatment strategies for pancreatic cancer in obese minority populations.
How similar studies have performed: While there is ongoing research into obesity and cancer, this specific focus on minority populations and pancreatic cancer mechanisms is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults 18 years of age or older at time of signing informed consent * Patients who self-report as African American, Non-Hispanic White * Patients who present to the gastrointestinal (GI) clinic, surgery, or endoscopy at a participating Florida Pancreas Collaborative (FPC) site or the University of Mississippi Medical Center (UMMC) with a clinical suspicion or diagnosis of a pancreatic tumor. Exclusion Criteria: * Patient under 18 years of age * Has no suspicion or diagnosis of a pancreatic cancer or tumor * Self-reported race/ethnicity other than African American or Non-Hispanic White.
Where this trial is running
Tampa, Florida and 1 other locations
- Moffitt Cancer Center — Tampa, Florida, United States (Recruiting)
- University of Mississippi Medical Center — Jackson, Mississippi, United States (Recruiting)
Study contacts
- Principal investigator: Jennifer Permuth, PhD, MS — Moffitt Cancer Center
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.