Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Evaluating how light affects neurological, psychiatric, and eye conditions

Official title: Study of the Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies

Run by University Hospital, Strasbourg, France · NCT03811964 · Data updated 2026-11-12

This study is testing how different types of light can affect mood, sleep, and brain health in people with various conditions, as well as in healthy individuals.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment726 (estimated)
SponsorUniversity Hospital, Strasbourg, France
Academic / other
Locations1 site (Strasbourg)
StatusRecruiting
StartedJanuary 22, 2020
Main results expectedJanuary 2028
Study endsFebruary 2028
Registry record updatedAugust 20, 2026
Trial IDNCT03811964 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adults aged 18 and older with sleep-wake disorders, neurological or psychiatric pathologies affecting sleep, ophthalmological conditions impacting photoreception, or healthy individuals for comparison.

Probably not a fit

Patients with significant vision loss due to conditions like Age-Related Macular Degeneration or cataracts may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the non-visual effects of light on various health conditions, including sleep disorders, neurological, psychiatric, and ophthalmological pathologies. It aims to understand how light influences behavior, mood, cognition, and sleep through specific light exposures. By examining these effects, the study seeks to establish new therapeutic applications for patients suffering from these conditions. Participants will be grouped based on their specific health issues or as healthy controls to assess the varying impacts of light exposure.

Why it matters

Potential benefit: If successful, this study could lead to new light-based therapies for managing sleep and mood disorders in patients with neurological, psychiatric, and ophthalmological conditions.

How similar studies have gone: While the specific approach of this study may be novel, there is growing interest in the therapeutic effects of light in related fields, suggesting potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Man or woman
* Aged 18 years or older
* Subject having signed a free and informed consent
* Subject affiliated to a social protection scheme Arm 1 :Subjects with primary sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric pathology pathology with disorder of the controls of the wake and the sleep Arm 4 : subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with regulation disorder of sleep and wake Arm 6 : healthy subject

Exclusion Criteria:

Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa, macular involvement of diabetes)

* Cataract with significant vision loss \<5/10
* Chorioretinal neovascularization
* Subject in exclusion period determined by previous or current study
* Impossibility to give the subject information enlightened (subject in emergency situation, difficulties of understanding the subject, ...)
* Subject under the protection of justice
* Subject under guardianship or curatorship
* Pregnancy / Breastfeeding

Where it's running

  • University Hospital, Strasbourg, France
    Strasbourg, France
    Recruiting

Study contacts

  • Principal investigator: Bourgin Patrice, MD — University Hospital, Strasbourg, France
  • Study coordinator: Bourgin Patrice, MD
  • Email: pbourgin@unistra.fr
  • Phone: 03 88 11 64 30

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.