Evaluating how light affects neurological, psychiatric, and eye conditions
Study of the Photomotor Reflex to Evaluate the Role of the Non-visual Effects of Light in Neurological, Psychiatric and Ophthalmological Pathologies
This study is testing how different types of light can affect mood, sleep, and brain health in people with various conditions, as well as in healthy individuals.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 726 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Strasbourg, France Academic / other |
| Locations | 1 site (Strasbourg) |
| Trial ID | NCT03811964 on ClinicalTrials.gov |
What this trial studies
This study investigates the non-visual effects of light on various health conditions, including sleep disorders, neurological, psychiatric, and ophthalmological pathologies. It aims to understand how light influences behavior, mood, cognition, and sleep through specific light exposures. By examining these effects, the study seeks to establish new therapeutic applications for patients suffering from these conditions. Participants will be grouped based on their specific health issues or as healthy controls to assess the varying impacts of light exposure.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older with sleep-wake disorders, neurological or psychiatric pathologies affecting sleep, ophthalmological conditions impacting photoreception, or healthy individuals for comparison.
Not a fit: Patients with significant vision loss due to conditions like Age-Related Macular Degeneration or cataracts may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to new light-based therapies for managing sleep and mood disorders in patients with neurological, psychiatric, and ophthalmological conditions.
How similar studies have performed: While the specific approach of this study may be novel, there is growing interest in the therapeutic effects of light in related fields, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Man or woman * Aged 18 years or older * Subject having signed a free and informed consent * Subject affiliated to a social protection scheme Arm 1 :Subjects with primary sleep-wake disorder Arm 2 : subjects presenting a neurological pathology with disorder of the controls of the wake and the sleep Arm 3 : subject presenting a psychiatric pathology pathology with disorder of the controls of the wake and the sleep Arm 4 : subject presenting an ophthalmological pathology with possible alteration of the photoreception and / or phototransduction Arm 5 : subjects with photosensitivity with regulation disorder of sleep and wake Arm 6 : healthy subject Exclusion Criteria: Age-Related Macular Degeneration (AMD) and all maculopathies (retinopathies pigmentosa, macular involvement of diabetes) * Cataract with significant vision loss \<5/10 * Chorioretinal neovascularization * Subject in exclusion period determined by previous or current study * Impossibility to give the subject information enlightened (subject in emergency situation, difficulties of understanding the subject, ...) * Subject under the protection of justice * Subject under guardianship or curatorship * Pregnancy / Breastfeeding
Where this trial is running
Strasbourg
- University Hospital, Strasbourg, France — Strasbourg, France (Recruiting)
Study contacts
- Principal investigator: Bourgin Patrice, MD — University Hospital, Strasbourg, France
- Study coordinator: Bourgin Patrice, MD
- Email: pbourgin@unistra.fr
- Phone: 03 88 11 64 30
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.