Evaluating how genetic variation affects insulin secretion in healthy individuals
Effect of Genetic Variation in the GLP-1 Receptor on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetic Humans
This study is testing how certain genetic differences affect insulin secretion in healthy people to see if a new treatment can improve their beta-cell function.
Quick facts
| Phase | Phase 3 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 25 Years to 65 Years |
| Sex | All |
| Sponsor | Mayo Clinic Academic / other |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT04466566 on ClinicalTrials.gov |
What this trial studies
This study investigates the impact of genetic variations in the GLP-1 receptor gene on insulin secretion during fasting and elevated blood sugar levels in nondiabetic individuals. It aims to recruit 40 participants aged 25-65, with a focus on those with specific genotypes related to the GLP1R gene. Participants will receive either saline or Exendin-9,39 to assess the effects on beta-cell function. The findings could enhance our understanding of insulin regulation in healthy individuals.
Who should consider this trial
Good fit: Ideal candidates are nondiabetic individuals aged 25-65 with specific genetic variations in the GLP1R gene.
Not a fit: Patients outside the age range of 25-65 or those with diabetes will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved insights into insulin secretion mechanisms, potentially influencing future diabetes prevention strategies.
How similar studies have performed: While studies on genetic variations affecting insulin secretion exist, this specific approach focusing on the GLP1R gene in healthy individuals is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 40 nondiabetic subjects will be recruited. * 20 subjects with the AA genotype at rs3765467 and remainder will have the GG genotype. * Individuals encompassing the age span of 25-65 years. Exclusion Criteria: * Individuals under 25 and over 65 years of age.
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (Recruiting)
Study contacts
- Principal investigator: Adrian Vella, MD — Mayo Clinic
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.