Evaluating how different wrist positions affect the median nerve in hypermobile patients
Ultrasonographic Evaluation of the Effects of Different Wrist Positions on the Median Nerve in Patients With Generalized Joint Hypermobility
This study is testing how different wrist positions affect the median nerve in women with joint hypermobility to see if certain positions cause more strain on the nerve.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 36 (estimated) |
| Ages | 15 Years to 45 Years |
| Sex | Female |
| Sponsor | Istanbul Physical Medicine Rehabilitation Training and Research Hospital Government |
| Locations | 1 site (Istanbul, Bahçelievler) |
| Trial ID | NCT06918613 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the impact of various wrist positions (neutral, flexion, extension, and ulnar deviation) on the morphology of the median nerve in patients with generalized joint hypermobility (GJH) using ultrasonography. It will involve 18 female patients diagnosed with GJH and 18 healthy controls, with a total of 72 wrists evaluated. The study will measure the cross-sectional area, perimeter, and circularity of the median nerve in different wrist positions to determine deformation ratios. The findings may provide insights into the relationship between wrist positioning and median nerve deformability in hypermobile individuals.
Who should consider this trial
Good fit: Ideal candidates are females aged 15-45 diagnosed with generalized joint hypermobility.
Not a fit: Patients with wrist pain, carpal tunnel syndrome, or other significant hand/wrist conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of median nerve behavior in hypermobile patients, potentially leading to better management strategies for related symptoms.
How similar studies have performed: While similar studies on median nerve evaluation exist, this specific approach focusing on wrist positions in hypermobile patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * 15-45 years of age * Female gender * Diagnosed with GJH according to the hypermobility spectrum disorders definition * Patients who agree to participate in the study and provide written consent Exclusion Criteria: * Having wrist pain * Inability to complete full range of motion in the wrist joint * Patients diagnosed with carpal tunnel syndrome * Anatomical abnormalities (bifid median nerve, aberrant persistent median artery, Martin-Gruber or other anastomoses) * History of trauma, operation, fracture, or steroid injection of the hand/wrist * History of known rheumatological, hereditary, genetic disease, or connective tissue disease other than GJH * Having neurological disease affecting hand functions (cervical radiculopathy, peripheral nerve lesion, polyneuropathy, cerebrovascular event, etc.) * Patients with history of regular steroid or non-steroid use, receiving oral glucosamine/hyaluronate supplementation * Those with systemic diseases (inflammatory joint diseases, diabetes mellitus, acromegaly, hypothyroidism, kidney failure, etc.) * Having a body mass index (BMI) of 30 or above, or history of morbid obesity * Being pregnant or in lactation period * Presence of malignancy
Where this trial is running
Istanbul, Bahçelievler
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital — Istanbul, Bahçelievler, Turkey (Recruiting)
Study contacts
- Study coordinator: İsmet Alkım Özkan
- Email: dr.alkimozkan@gmail.com
- Phone: 5356350591
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.