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Clinical trial Recruiting at 21 sites Observational Ages 18 and up

Evaluating how complexity and multiple illnesses affect hospitalized patients' health

Official title: EFFECTS OF COMPLEXITY AND MULTIMORBIDITY ON CLINICAL OUTCOMES IN HOSPITALIZED INTERNAL MEDICINE PATIENTS

Run by Società Italiana di Medicina Interna · NCT06872632 · Data updated 2026-11-12

This study is trying to see how having multiple health issues affects the recovery and overall health of adults in the hospital.

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Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment2326 (estimated)
SponsorSocietà Italiana di Medicina Interna
Academic / other
Locations21 sites (San Fermo della Battaglia, CO and 20 other locations)
StatusRecruiting
StartedJune 24, 2024
Main results expectedSeptember 2029
Study endsSeptember 2030
Registry record updatedNovember 2, 2026
Trial IDNCT06872632 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adult patients aged 18 and older who are hospitalized in internal medicine units.

Probably not a fit

Patients who are not hospitalized or those who do not have multiple illnesses may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the relationship between the complexity of multiple illnesses in adult hospitalized patients and various clinical outcomes, including mortality. It will analyze pre-existing factors at the time of hospitalization and their impact on outcomes such as length of stay, intensity of care, complications, and rehospitalization rates. The study will enroll participants over four index weeks, with a target of 2,326 participants across multiple centers, followed by a 12-month follow-up period.

Why it matters

Potential benefit: If successful, this study could provide insights that improve the management and treatment of complex, multi-morbid patients in hospital settings.

How similar studies have gone: While similar studies have explored the impact of multiple illnesses on health outcomes, this specific approach focusing on hospitalized patients is relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

1. age \>= 18 years
2. Informed consent according to Italian law.

Exclusion Criteria:

* No specific exclusion criteria were identified.

Where it's running

  • ASST Lariana - Ospedale Sant'Anna di San Fermo della Battaglia - UOC Medicina Generale
    San Fermo della Battaglia, Co, Italy     Recruiting
  • ASP di Catanzato - Presidio Ospedaliero "Giovanni Paolo II" di Lamezia Terme
    Catanzaro, Cz, Italy     Recruiting
  • AOU "Dulbecco" di Catanzaro - Presidio Ospedaliero di Germaneto - UOC Geriatria
    Catanzaro, Cz, Italy     Recruiting
  • AOU Careggi - SOD Medicina Interna 4
    Florence, Fi, Italy     Recruiting
  • AOU Policlinico di Bari - UO Medicina Interna
    Bari, Italy, Italy     Recruiting
  • AOU Policlinico S. Orsola-Malpighi - UO Medicina interna, malattie epatobiliari e immunoallergologiche
    Bologna, Italy, Italy     Recruiting
Show 15 more locations
  • ASST degli Spedali Civili di Brescia - UO di Medicina Generale 2
    Brescia, Italy, Italy     Recruiting
  • Ospedale Santa Maria Annunziata, Bagno a Ripoli - UOC di Medicina 1
    Florence, Italy, Italy     Recruiting
  • ASST Fatebenefratelli Sacco - Ospedale Luigi Sacco - SC di Medicina Interna
    Milan, Italy, Italy     Recruiting
  • AOU Policlinico di Modena - UOC Medicina Interna
    Modena, Italy, Italy     Recruiting
  • AOU Federico II di Napoli - UOC Medicina Interna ad indirizzo metabolico e riabilitativo
    Naples, Italy, Italy     Recruiting
  • AOU Maggiore della Carità - UOC di Medicina Interna 1
    Novara, Italy, Italy     Recruiting
  • Policlinico Universitario Campus Bio-Medico di Roma - UOC di Medicina Interna
    Roma, Italy, Italy     Recruiting
  • AOU Sant'Andrea - UOC di Medicina Interna
    Roma, Italy, Italy     Recruiting
  • AOU Policlinico G. Martino - UOC Medicina Interna
    Messina, Me, Italy     Recruiting
  • ASST Grande Ospedale Metropolitano Niguarda - UOC Medicina Interna - Alta Complessità Medica
    Milan, Mi, Italy     Recruiting
  • Fondazione Policlinico Universitario Tor Vergata - UOC Medicina Interna Centro Medico per l'Obesità
    Roma, Rm, Italy     Recruiting
  • AOU Policlinico Umberto I - UOC Medicina Interna e Nutrizione Clinica
    Roma, Rm, Italy     Recruiting
  • IRCCS Ospedale San Raffaele - UO di Medicina Generale ad Indirizzo Specialistico e della Continuità Assistenziale
    Roma, Rm, Italy     Recruiting
  • ASL 5 - Presidio Ospedaliero San Bartolomeo di Sarzana - UO di Clinica Medica Interna e Immunologia
    Sarzana, Sp, Italy     Recruiting
  • ASST Sette Laghi - Ospedale di Circolo di Varese
    Varese, VA, Italy     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.