Evaluating how atrial fibrosis affects atrial fibrillation risk in stroke patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between the surface area of atrial fibrosis and the occurrence of atrial fibrillation in patients who have experienced an ischemic stroke of unknown origin. It utilizes cardiac MRI imaging to assess the left atrium and aims to improve the selection process for patients who may benefit from implantable loop recorders. By identifying patients at higher risk for atrial fibrillation, the study seeks to enhance long-term monitoring and treatment strategies. The study involves patients who have had a cryptogenic ischemic stroke within the last 30 days and are scheduled for loop recorder implantation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patient who has provided free, written and informed consent
* Patient of legal age
* Patient with cryptogenic ischemic stroke within 30 days of inclusion, documented by brain imaging (cerebral angioscan or cerebral MRI)
* Patients scheduled for implantable loop recorder implantation within 3 months of ischemic stroke in search of silent AF:

  * cryptogenic ischemic stroke or stroke with probable cardioembolic cause
  * no history of atrial fibrillation
  * no long-term anticoagulant therapy
  * with life expectancy \>12 months

Exclusion Criteria:

* Person not affiliated to national health insurance
* Person under legal protection (curatorship, guardianship)
* Person under court order
* Pregnant, parturient or breast-feeding
* Adult unable to give consent
* Patient diagnosed with AF during stroke assessment
* Patient with a contraindication to MRI or gadolinium injection:

  * Severe renal impairment (\<30ml/min Cockroft clearance due to gadolinium injection)
  * Claustrophobia / contraindication to MRI (metal implant not MRI compatible)
  * History of hypersensitivity to gadoteric acid or gadolinium-based contrast agents, and to meglumine
  * Uncontrolled asthma

Where it's running

• Chu Dijon Bourgogne
  Dijon, France Recruiting

Study contacts

• Study coordinator: Charles GUENANCIA
• Email: charles.guenancia@chu-dijon.fr
• Phone: 0380295623

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.