Evaluating high-resolution electrical imaging for epilepsy surgery in children

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of high-resolution electrical source imaging (HR-ESI) in assessing children with drug-resistant focal epilepsy before surgery. The approach involves using scalp electrodes to estimate the brain's electrical sources and fusing this data with structural MRI images. By analyzing the accuracy of HR-ESI in predicting surgical outcomes, the study aims to improve the presurgical evaluation process for pediatric patients. The research focuses on children aged 2 to 17 who have not responded to at least two anti-epileptic drug trials.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age≥2 and \<17 years;
2. Drug-resistant focal epilepsy (failure of at least 2 well-conducted drug trials);
3. Phase 1 pre-op evaluation with scalp video-EEG recording, MRI and PET-FDG suggesting that the patient could be a good candidate for epilepsy surgery;
4. Recent scalp EEG record (within 12 months) showing the presence of interictal spikes;
5. High-quality and recent (within 6 months) structural MRI with 3D-T1 sequences covering the whole brain and the scalp available.

Exclusion Criteria:

1. Behavioral deficits making recording of scalp EEG impossible without sedation;
2. Informed consent form not signed by the parents;
3. Patient not affiliated to a social security system

Where it's running

• Angers university hospital, Pédiatric department
  Angers, France Recruiting
• Lille University Hospital, Clinical Neurophysiology Department
  Lille, France Not yet recruiting
• Civil Hospices of Lyon, Functional Neurology Department
  Lyon, France Not yet recruiting
• Marseille Timone University Hospital, Epileptology and Cerebral Rhythmology Department
  Marseille, France Not yet recruiting
• Nancy University Hospital, Neurology Department
  Nancy, France Not yet recruiting
• Paris Neck University Hospital, Pediatric department
  Paris, France Not yet recruiting

Study contacts

• Study coordinator: Patrick Van Bogaert, Professor
• Email: Patrick.VanBogaert@chu-angers.fr
• Phone: +33 2 41 35 48 46

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.