Evaluating High Flow Nasal Cannula Effects on Infants with Bronchiolitis
Evaluation of Pulmonary Aeration and Muscle Thickening Fraction in Infants With Bronchiolitis Using a High-flow Nasal Cannula: Association of Electrical Impedance Tomography and Ultrasound
This study is testing how different flow rates of High Flow Nasal Cannula can help infants under 2 with bronchiolitis by looking at their breathing and muscle function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 82 (estimated) |
| Ages | N/A to 24 Months |
| Sex | All |
| Sponsor | Hospital Israelita Albert Einstein Academic / other |
| Locations | 1 site (São Paulo) |
| Trial ID | NCT06376487 on ClinicalTrials.gov |
What this trial studies
This clinical study aims to assess how different flow rates of High Flow Nasal Cannula (HFNC) affect the thickening fraction of abdominal and diaphragm muscles in infants under 2 years old diagnosed with bronchiolitis. The study will utilize Electrical Impedance Tomography (EIT) to monitor changes in lung impedance and functional residual capacity (FRC) during varying flow rates. Continuous monitoring will be conducted in a pediatric ICU setting to gather data on respiratory distress and potential failure criteria for HFNC therapy.
Who should consider this trial
Good fit: Ideal candidates for this study are infants under 2 years old diagnosed with bronchiolitis who require HFNC treatment.
Not a fit: Patients with chronic diseases may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of bronchiolitis in infants by optimizing HFNC therapy.
How similar studies have performed: While the approach of using EIT in this context is relatively novel, similar studies have shown promise in optimizing respiratory therapies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Diagnosis of bronchiolitis * Use of HFNC Exclusion Criteria: * Patients diagnosed with chronic diseases
Where this trial is running
São Paulo
- Hospital Israelita Albert Eisntein — São Paulo, Brazil (Recruiting)
Study contacts
- Principal investigator: Milena S Nascimento — Hospital Israelita Albert Einstein
- Study coordinator: Milena S Nascimento
- Email: milena.nascimento@einstein.br
- Phone: 55 11 984520061
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.