Evaluating hemodynamic stability in septic shock patients using a new dialysis membrane
Real-time Monitoring of Hemodynamic Stability in Septic Shock Patients Undergoing Continuous Renal Replacement Therapy: Propensity Score-matched Comparison Between oXiris and Polysulfone Membranes
This study is testing if a new dialysis membrane can help patients with severe kidney injury from sepsis feel better and have improved heart and kidney function compared to standard treatments.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 98 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Seoul National University Hospital Academic / other |
| Locations | 1 site (Seoul) |
| Trial ID | NCT05575024 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the effectiveness of the oXiris membrane in continuous renal replacement therapy (CRRT) for patients suffering from severe acute kidney injury due to sepsis. It aims to compare the hemodynamic stability and patient outcomes, such as cardiovascular and renal function, between the oXiris membrane and standard polysulfone membranes. The study utilizes a real-time monitoring registry to gather data on cytokine and endotoxin removal rates, as well as overall survival rates. The goal is to determine if the oXiris membrane can provide better clinical outcomes than traditional methods.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 years and older who have sepsis-related acute kidney injury requiring continuous renal replacement therapy.
Not a fit: Patients who do not require monitoring of blood pressure and ECG will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved hemodynamic stability and better survival rates for patients with septic shock and acute kidney injury.
How similar studies have performed: While the oXiris membrane has shown promise in reducing cytokines and endotoxins, this specific comparison of hemodynamic stability with standard membranes is novel and has not been thoroughly evaluated in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged ≥ 18 years * Sepsis related acute kidney injury requiring continuous renal replacement therapy Exclusion Criteria: • No monitoring of blood pressure and ECG
Where this trial is running
Seoul
- Seoul National University Hospital — Seoul, South Korea (Recruiting)
Study contacts
- Principal investigator: Seung Seok Han, M.D. — Seoul National University Hospital
- Study coordinator: Seung Seok Han, M.D.
- Email: hansway7@snu.ac.kr
- Phone: 82-2-2072-4785
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.