Evaluating heart rate variability after different ablation methods for atrial fibrillation
Evaluation of Heart Rate Variability in Patients After Ablation Using Pulsed Field and Radiofrequency
This study is testing whether a new type of heart procedure called pulsed-field ablation is better for heart rate control than the traditional method in patients with a type of irregular heartbeat called atrial fibrillation.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Charles University, Czech Republic Academic / other |
| Locations | 1 site (Prague) |
| Trial ID | NCT06276296 on ClinicalTrials.gov |
What this trial studies
This observational study aims to compare the effects of pulsed-field ablation and traditional radiofrequency ablation on heart rate variability in patients with paroxysmal atrial fibrillation. By measuring heart rate variability using a 24-hour Holter ECG before and after the ablation procedures, the study seeks to determine whether pulsed-field ablation causes less disruption to the autonomic nervous system compared to radiofrequency ablation. The study is conducted at Charles University and University Hospital Královské Vinohrady in Prague, focusing on patients who are candidates for catheter ablation due to atrial fibrillation.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with paroxysmal atrial fibrillation who require catheter ablation.
Not a fit: Patients with continuous atrial fibrillation or significant valve disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved ablation techniques that minimize autonomic nervous system disruption, potentially enhancing patient outcomes.
How similar studies have performed: Previous studies have suggested that pulsed-field ablation may offer advantages over traditional methods, indicating a promising area of investigation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * paroxysmal atrial fibrillation * indication for catheter ablation due to atrial fibrillation * willingness to participate Exclusion Criteria: * atrial fibrillation throughout Holter ECG recording * significant valve disease * left ventricular dysfunction, EF less than 35%
Where this trial is running
Prague
- Cardiocenter, 3rd Medical School, Charles University and University Hospital Kralovske Vinohrady — Prague, Czechia (Recruiting)
Study contacts
- Study coordinator: Jana Vesela, Ph.D.
- Email: janca.zd@gmail.com
- Phone: +420267162714
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.