Evaluating Heart Imaging Techniques Using MRI and PET
COMPLEMENTARY INVESTIGATION OF PERFUSION AND ANATOMY MEASURES OF THE HEART WITH MRI AND COMBINED PET/MRI
University of Zurich · NCT05609214
This study is trying to see if using both MRI and PET scans together can give doctors better information to help patients with coronary artery disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Zurich (other) |
| Locations | 1 site (Zurich) |
| Trial ID | NCT05609214 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the complementary information provided by MRI and PET imaging techniques in evaluating coronary artery disease. It focuses on comparing the perfusion and anatomical measurements obtained from both imaging modalities and estimating their prognostic values. The study also seeks to optimize routine scanning procedures to enhance the completeness and value of quantitative measurements. By integrating these advanced imaging techniques, the research hopes to improve the assessment of patients with known or suspected ischemic heart disease.
Who should consider this trial
Good fit: Ideal candidates include adults over 18 years with symptoms consistent with possible coronary artery disease who are referred for a vasodilator stress CMR and/or PET examination.
Not a fit: Patients with severe claustrophobia, advanced renal disease, or specific contraindications to CMR will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic accuracy and treatment strategies for patients with coronary artery disease.
How similar studies have performed: Other studies have shown success in using combined imaging techniques for cardiac assessment, indicating a promising approach in this area.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Male and Female participants over the age of 18 years * Written informed consent by the participant after information about the research project * Symptoms consistent with possible coronary artery disease * Clinical referral for a vasodilator stress CMR and/or PET examination Exclusion Criteria: * Patients with high degree heart block * Contraindications to gadolinium-enhanced CMR examination * Severe claustrophobia * Specific implantable devices which are contraindicated for CMR * Current pregnancy * Advanced renal disease (GFR\<30) * Uncontrolled obstructive pulmonary disease or asthma * Atrial fibrillation at the time of study enrolment
Where this trial is running
Zurich
- University Hospital Zurich — Zurich, Switzerland (RECRUITING)
Study contacts
- Principal investigator: Aju P Pazhenkottil — University of Zurich
- Study coordinator: Aju P Pazhenkottil, MD
- Email: aju.pazhenkottil@usz.ch
- Phone: +41792611965
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Coronary Artery Disease, Myocardial Perfusion