Evaluating heart function and reserve in healthy adults
CArdioMEtabolic Function and Reserve Capacity in Healthy Adults: The CAMERA Study
NA · Mayo Clinic · NCT06220396
This study is testing how healthy people's hearts work during rest and exercise to learn more about cardiovascular health in the general population.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 30 Years and up |
| Sex | All |
| Sponsor | Mayo Clinic (other) |
| Locations | 1 site (Rochester, Minnesota) |
| Trial ID | NCT06220396 on ClinicalTrials.gov |
What this trial studies
This study aims to assess pulmonary capillary wedge pressure and other hemodynamic measurements in healthy volunteers during rest and exercise. Participants will undergo right heart catheterization, MRI, and DEXA scans to gather comprehensive data on cardiovascular function. The study focuses on individuals across various age groups who are free from heart-related symptoms or diagnoses. By analyzing these measurements, researchers hope to better understand cardiovascular health in the general population.
Who should consider this trial
Good fit: Ideal candidates are healthy adults without symptoms of exertional breathlessness or fatigue and with a left ventricular ejection fraction of 50% or greater.
Not a fit: Patients with any history of heart failure, significant exertional symptoms, or other cardiovascular conditions will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance our understanding of cardiovascular health and reserve capacity in healthy individuals, potentially leading to improved preventive strategies.
How similar studies have performed: While this study focuses on healthy individuals, similar studies assessing cardiovascular function in different populations have shown promising results, indicating the potential for valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Apparently healthy volunteers are eligible to participate in this study if they are free of symptoms of exertional breathlessness or fatigue and any diagnosis of heart failure. * Patients will also be required to have left ventricular ejection fraction (EF) ≥ 50%. * Patients discovered to reduced EF or abnormal resting hemodynamics or other pathologic findings previously undiscovered will be considered screen failures and can be replaced by others to reach the goal enrollment. * Informed consent were obtained. * No history of heart failure. * Willing and able to undergo invasive hemodynamic exercise testing, MRI, and other study assessments. Exclusion Criteria: * Clinically significant symptoms of exertional dyspnea or fatigue in daily life in the opinion of the investigators. * Any diagnosis of heart failure * Symptomatic coronary artery disease (e.g., patients with chronic angina) * Symptomatic valvular heart disease * Pulmonary hypertension * Cardiomyopathies * High output heart failure * Pericardial disease * Clinically significant chronic lung disease in the opinion of the investigators * Anemia (hemoglobin \<12 gm/dL in women and \<13 gm/dL in men) * Estimated glomerular filtration rate ≤30mL/min * Pregnant women * Any other disorders or problems that would interfere with the ability to participate safely in the study (e.g. psychiatric disorder or substance abuse)
Where this trial is running
Rochester, Minnesota
- Mayo Clinic in Rochester — Rochester, Minnesota, United States (RECRUITING)
Study contacts
- Principal investigator: Barry Borlaug, MD — Mayo Clinic
- Study coordinator: Alyssa Ploof
- Email: ploof.alyssa@mayo.edu
- Phone: 507-255-0463
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Healthy