Evaluating heart failure patients in Singapore receiving cardiac resynchronization therapy
Prospective Evaluation of Asians With CRT for Heart Failure
This study looks at heart failure patients in Singapore receiving a specific heart treatment to see how their health changes over a year and what factors might help predict their response to the treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 500 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | National University Heart Centre, Singapore Academic / other |
| Locations | 1 site (Singapore) |
| Trial ID | NCT02814942 on ClinicalTrials.gov |
What this trial studies
This observational study aims to assess the baseline characteristics and long-term outcomes of heart failure patients in Singapore who are undergoing cardiac resynchronization therapy (CRT). It collects demographic data, ECG parameters, echocardiographic measurements, and blood biomarkers before and after the CRT procedure. The study will analyze these factors to identify predictors of response to CRT, defined by specific changes in left ventricular function over a 12-month period. The findings may help improve patient selection and treatment strategies for CRT in heart failure.
Who should consider this trial
Good fit: Ideal candidates for this study are adults with symptomatic heart failure, a broad QRS duration greater than 120 ms, and an ejection fraction of less than 40% who are not on optimal medical therapy.
Not a fit: Patients who are pregnant, under 18 years of age, have an active infection, or are unable to provide consent may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the understanding of which heart failure patients are most likely to benefit from CRT, leading to better treatment outcomes.
How similar studies have performed: Other studies have shown success in evaluating CRT outcomes in diverse populations, but this specific focus on Asian patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Broad QRS (\>120 ms) * EF \< 40% * Symptomatic heart failure * Not on optimal medical therapy Exclusion Criteria: * Pregnant * \< 18 years of age * Infection * Unable to consent
Where this trial is running
Singapore
- National University Hospital — Singapore, Singapore (Recruiting)
Study contacts
- Principal investigator: Swee Chong Seow, MD — National University Hospital, Singapore
- Study coordinator: Pipin Kojodjojo, MD PHD
- Phone: 67795555
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.