Evaluating heart changes in patients with severe mitral regurgitation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the feasibility of a larger future study that will utilize cardiac CT and MRI to evaluate the risk of developing left ventricular systolic dysfunction in patients diagnosed with severe chronic primary mitral regurgitation. Participants will undergo isolated robotic mitral annuloplasty at the Mayo Clinic in Rochester, Minnesota. The study will focus on understanding how these imaging modalities can help in predicting heart function changes in this patient population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \>= 18
* Male or Female
* A diagnosis of severe chronic primary mitral regurgitation
* Undergoing isolated robotic mitral annuloplasty at Mayo Clinic Rochester
* Patients must have the ability to consent or have an appropriate representative available to do so.

Exclusion Criteria:

* Prior valve intervention,
* Concomitant valve surgery at the time of mitral annuloplasty (e.g. tricuspid annuloplasty, aortic valve replacement).
* Concomitant \>= moderate regurgitation or stenosis in any other valve by preoperative echocardiography
* History of prior myocardial infarction
* History of cardiomyopathy unrelated to mitral regurgitation (e.g. dilated, hypertrophic, infiltrative)
* Pregnancy. Women of childbearing potential will be verbally screened by clinical staff during as part of routine pre-MRI evaluation. If a subject is unsure whether they could be pregnant, a negative pregnancy test will be performed prior to scanning.
* Implantable devices that would be a contraindication to MRI
* Severe allergy to gadolinium MRI contrast

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Arman Arghami, MD, MPH — Mayo Clinic
• Study coordinator: Cardiovascular Surgical Research
• Email: cvsurgresearch@mayo.edu
• Phone: (507) 266-7982

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Gastric Ultrasound Before CABG to See if Heart Function Changes Stomach Contents

  This study checks whether people with weaker heart function before elective CABG have different stomach contents seen on ultrasound.

  Recruiting Adiyaman University · Adıyaman · NCT07898215

• Safe, long-term finerenone for children and young adults with heart failure and LV dysfunction

  This study tests whether finerenone can be safely used over a long period in children and young adults who have heart failure due to left ventricular systolic dysfunction.

  Recruiting at 13 sites Phase 3 Bayer · Aurora, Colorado and 131 other locations · NCT07192952

• Finerenone versus placebo added to usual care for children with heart failure and reduced left ventricular pumping

  This will test whether finerenone, given with standard heart-failure treatment, helps children aged 6 months to under 18 with reduced left ventricular function compared with placebo.

  Recruiting at 20 sites Phase 3 Bayer · Aurora, Colorado and 132 other locations · NCT07188805

• Oral sucrosomial iron's effect on exercise and quality of life in heart failure patients

  This study is testing if a new type of oral iron can help people with heart failure and low iron feel better and exercise more easily compared to a placebo.

  Recruiting Phase 4 Azienda Ospedaliero, Universitaria Pisana · Pisa, Tuscany · NCT06270498

• Evaluating vericiguat for heart failure in children

  This study is testing if a new heart medication called vericiguat can help children with heart failure feel better and improve their health compared to a placebo.

  Recruiting at 91 sites Phase 2/3 Merck Sharp & Dohme LLC · Los Angeles, California and 111 other locations · NCT05714085

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.