Evaluating heart and lung function changes after thrombolysis in pulmonary embolism patients
Dynamic Changes of Circulatory and Respiratory Function After Thrombolysis in Patients With Acute Pulmonary Embolism
This study is testing how well thrombolysis treatment helps improve heart and lung function in patients with acute pulmonary embolism.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 80 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Trial ID | NCT04757129 on ClinicalTrials.gov |
What this trial studies
This observational study aims to enroll 80-100 patients diagnosed with acute pulmonary embolism who are treated with thrombolysis at two hospitals in Nanjing. The researchers will monitor dynamic changes in cardiopulmonary function post-thrombolysis, assessing various indicators such as blood pressure, heart rate, respiratory rate, and echocardiographic measurements. Participants will be categorized into thrombolytic success and failure groups based on established criteria evaluated 48 hours after treatment. The goal is to identify rapid and accurate indicators that reflect the effectiveness of thrombolysis in these patients.
Who should consider this trial
Good fit: Ideal candidates include individuals with medium-high or high-risk pulmonary embolism who are eligible for thrombolysis treatment.
Not a fit: Patients who lack radiologic evidence of pulmonary embolism or those who die within 48 hours post-treatment may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide critical insights into the effectiveness of thrombolysis, leading to improved treatment protocols for acute pulmonary embolism.
How similar studies have performed: While there have been studies on thrombolysis in pulmonary embolism, this specific approach to dynamically monitor cardiopulmonary function is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * medium-high risk or high risk pulmonary embolism and treated with thrombolysis Exclusion Criteria: * lack of radiologic evidence to diagnose APE * death within 48 hours after thrombolytic therapy * unable to partner treatment and leaving hospitals * missing other necessary data * pregnancy
Where this trial is running
Nanjing, Jiangsu
- the First Affiliated Hospital with Nanjing Medical University — Nanjing, Jiangsu, China (Recruiting)
Study contacts
- Study coordinator: Bin He, Master
- Email: hbhbwywy34@sina.com
- Phone: 13770789159
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.